{"id":"W4408665468","doi":"10.1021/acsmedchemlett.4c00592","title":"Design, Synthesis, and Evaluation of a New Fluorescent Ligand for the M<sub>2</sub> Muscarinic Acetylcholine Receptor","year":2025,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development","funders":"European Regional Development Fund; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal; Xunta de Galicia; Magyar Tudományos Akadémia; European Commission","keywords":"Muscarinic acetylcholine receptor; Acetylcholine receptor; Ligand (biochemistry); Acetylcholine; Fluorescence; Muscarinic acetylcholine receptor M5; Chemistry; Computer science; Muscarinic acetylcholine receptor M3; Biophysics; Combinatorial chemistry; Receptor; Pharmacology; Medicine; Biochemistry; Biology; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001011582,0.0001603546,0.0001818976,0.00002003036,0.00009374498,0.00001566552,0.0001903486,0.0001263548,0.00001505579],"category_scores_gemma":[0.0004299541,0.0001222988,0.00007112631,0.00007962217,0.00009847469,0.000003511577,0.00006016538,0.00009844402,4.175545e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002759488,"about_ca_system_score_gemma":0.0001837059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008989929,"about_ca_topic_score_gemma":0.000001188906,"domain_scores_codex":[0.9989312,0.00004916393,0.0002564151,0.0003067786,0.00026483,0.0001916611],"domain_scores_gemma":[0.9992598,0.0001455029,0.0001179436,0.000278049,0.000131987,0.00006671352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001635931,0.00001602597,0.00002186627,0.00008665922,0.000123199,1.774364e-7,0.0000645393,0.0001596006,0.9689167,0.00000269554,0.007113458,0.02333153],"study_design_scores_gemma":[0.0009068046,0.00003729777,0.00003938368,0.0001341141,0.0002912141,0.000004180241,0.0001459373,0.0004656029,0.9964716,0.00004391276,0.00134705,0.0001129465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9641029,0.002936757,0.02960993,0.002724568,0.0001658422,0.0004281849,0.000007350687,0.00000652043,0.00001796559],"genre_scores_gemma":[0.9973743,0.0005964215,0.0007925276,0.0006652017,0.0003888428,0.00009572472,0.00004239223,0.00001554394,0.00002902878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03327144,"threshold_uncertainty_score":0.49872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02081444041704015,"score_gpt":0.2703035362684855,"score_spread":0.2494890958514454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}