{"id":"W4408665468","doi":"10.1021/acsmedchemlett.4c00592","title":"Design, Synthesis, and Evaluation of a New Fluorescent Ligand for the M<sub>2</sub> Muscarinic Acetylcholine Receptor","year":2025,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development","funders":"European Regional Development Fund; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal; Xunta de Galicia; Magyar Tudományos Akadémia; European Commission","keywords":"Muscarinic acetylcholine receptor; Acetylcholine receptor; Ligand (biochemistry); Acetylcholine; Fluorescence; Muscarinic acetylcholine receptor M5; Chemistry; Computer science; Muscarinic acetylcholine receptor M3; Biophysics; Combinatorial chemistry; Receptor; Pharmacology; Medicine; Biochemistry; Biology; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002614502,0.0003520538,0.000249555,0.0001418066,0.0001925147,0.0002607126,0.0004590752,0.0004346075,0.001635024],"category_scores_gemma":[0.0002028654,0.00015809,0.0001810742,0.0001254053,0.0002344772,0.0003143705,0.0002563408,0.0004304403,0.0007534716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004695705,"about_ca_system_score_gemma":0.0003913667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006140692,"about_ca_topic_score_gemma":0.0008443563,"domain_scores_codex":[0.9998856,0.00001917644,0.000008451942,0.00002481413,0.00003696074,0.00002500111],"domain_scores_gemma":[0.9999144,0.00001312686,0.00001950472,0.000007864146,0.00002274564,0.00002225126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003156073,0.0000218021,0.00003221158,0.00003015477,0.000002623989,0.00003907311,0.00001489965,0.0002022708,0.9970528,0.0001893187,0.00006790554,0.002315308],"study_design_scores_gemma":[0.00001676732,0.0002743912,0.0001920297,0.000002262952,0.00000537999,0.00008618777,0.00000964653,0.000951468,0.995353,0.00002550443,0.003078009,0.000005462044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8866018,0.001852469,0.1031967,0.0007636165,0.00005932962,0.0006376011,0.0005009636,0.0004290831,0.005958411],"genre_scores_gemma":[0.8274795,0.002555865,0.1524002,0.000443931,0.0000449385,0.0005897933,0.0009778606,0.0001216756,0.01538615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001635024,"threshold_uncertainty_score":0.00546968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02081444041704015,"score_gpt":0.2703035362684855,"score_spread":0.2494890958514454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}