{"id":"W4408667207","doi":"10.1093/stmcls/sxaf012","title":"Nephron progenitor fate is modulated by angiotensin type 1 receptor signaling in human kidney organoids","year":2025,"lang":"en","type":"article","venue":"Stem Cells","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Biology; Losartan; Nephron; Podocyte; Progenitor cell; Cell biology; Angiotensin II; Organoid; Kidney development; Cell fate determination; Population; Internal medicine; Kidney; Endocrinology; Induced pluripotent stem cell; Stem cell; Embryonic stem cell; Genetics; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002111929,0.0001359742,0.0002387763,0.0002092188,0.0001612449,0.0003376062,0.0001018407,0.0001477715,0.0007266482],"category_scores_gemma":[0.0001701498,0.0001143963,0.0001962681,0.0001463263,0.0001489678,0.0001081621,0.0001508255,0.0002492781,0.0002952942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002092431,"about_ca_system_score_gemma":0.0001965082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001049009,"about_ca_topic_score_gemma":0.0009661447,"domain_scores_codex":[0.9998989,0.0000188641,0.000009132857,0.0000273097,0.00003459297,0.00001113819],"domain_scores_gemma":[0.9999019,0.00004384683,0.00001454529,0.00001269271,0.00001392556,0.00001303866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000757932,0.000008661879,0.0005913794,0.00003350734,0.000006371076,0.00008998811,0.00007323403,0.0006410552,0.9967782,0.000115465,0.00002987976,0.001556411],"study_design_scores_gemma":[0.00000820171,0.0001096562,0.004474795,0.000006874799,0.00002851428,0.0001880873,0.00008440731,0.003927566,0.9878348,0.0001003299,0.0032265,0.00001016528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855132,0.001020168,0.01063159,0.00004049338,0.00001450162,0.00003967845,0.0008254212,0.0001064939,0.001808659],"genre_scores_gemma":[0.9912714,0.0006813268,0.005366602,0.00002162637,0.000002034668,0.00004717655,0.001046894,0.00002706875,0.001535927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001049009,"threshold_uncertainty_score":0.002430856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004772493376045065,"score_gpt":0.2242726071858815,"score_spread":0.2195001138098365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}