{"id":"W4408672942","doi":"10.1038/s41591-025-03592-z","title":"Single-cell profiling of the human endometrium in polycystic ovary syndrome","year":2025,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Novo Nordisk Fonden; Diabetesförbundet; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse","keywords":"Polycystic ovary; Metformin; Insulin resistance; Hyperandrogenism; Endometrium; Endometrial cancer; Medicine; Miscarriage; Internal medicine; Overweight; Polycystic ovarian disease; Endocrinology; Oncology; Obesity; Pregnancy; Biology; Insulin; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000123616,0.00007632363,0.0001697413,0.0004958232,0.0001871614,0.0002218875,0.00009160365,0.0002012928,0.0004062759],"category_scores_gemma":[0.0001418632,0.00008264386,0.0001418016,0.0003271817,0.0001257762,0.00008974161,0.0002167566,0.0001339442,0.0001591413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008925294,"about_ca_system_score_gemma":0.00008214627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005797634,"about_ca_topic_score_gemma":0.001646014,"domain_scores_codex":[0.999915,0.00001591392,0.000007568357,0.00002265021,0.00002454499,0.00001436253],"domain_scores_gemma":[0.9999535,0.00000900802,0.000007926589,0.000008750153,0.0000115204,0.000009312962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001501823,0.000007851524,0.01863358,0.00005283194,0.00001604272,0.0001803811,0.0001272361,0.00008139536,0.9746547,0.00004258612,0.0000562473,0.005996969],"study_design_scores_gemma":[0.00001434644,0.0003809494,0.7702875,0.00002790317,0.00006387076,0.003269564,0.0008850236,0.002136552,0.2168375,0.0002186832,0.005860473,0.00001766084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920374,0.003112903,0.003461883,0.0000609889,0.00001850702,0.00002427394,0.0005443202,0.00002612355,0.0007137203],"genre_scores_gemma":[0.99181,0.00165095,0.004848594,0.00006603614,0.000009118487,0.00003406811,0.0008296359,0.00001059623,0.000740975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005797634,"threshold_uncertainty_score":0.001359105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01081335063282019,"score_gpt":0.2607645330638166,"score_spread":0.2499511824309965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}