{"id":"W4408674214","doi":"10.3389/fragi.2025.1547883","title":"Rock inhibitors in Alzheimer’s disease","year":2025,"lang":"en","type":"review","venue":"Frontiers in Aging","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute on Aging","keywords":"Astrocytosis; Neuroinflammation; Gliosis; Neuroscience; Tauopathy; Senile plaques; Disease; Dementia; Microglia; Alzheimer's disease; Pathology; Biology; Medicine; Inflammation; Neurodegeneration; Immunology; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003418615,0.0008453352,0.001104774,0.001506432,0.0002467221,0.0007684332,0.0006419469,0.0007742429,0.004911471],"category_scores_gemma":[0.0003737673,0.0002126926,0.0006428696,0.00105181,0.0002297357,0.0007338319,0.0006083061,0.001924627,0.002537414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003547857,"about_ca_system_score_gemma":0.0006278358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008219167,"about_ca_topic_score_gemma":0.001841465,"domain_scores_codex":[0.9998859,0.00001605918,0.00001615792,0.00002090903,0.00004462095,0.00001634041],"domain_scores_gemma":[0.9999046,0.00003470273,0.00001776998,0.000003105494,0.00002687021,0.00001299289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001749423,0.0001321193,0.00008209354,0.01960242,0.0001277328,0.0001891326,0.00006406684,0.0003545094,0.003364195,0.00301233,0.03024832,0.9426482],"study_design_scores_gemma":[0.00007281928,0.0002510911,0.0006696043,0.003660734,0.0001994526,0.0008252148,0.00003736206,0.0000993298,0.0009369256,0.001387039,0.9918414,0.00001901843],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000265719,0.9981481,0.00007731065,0.0001353653,0.000210338,0.00000866763,0.00002896019,0.00001286923,0.001112645],"genre_scores_gemma":[0.001137493,0.9973415,0.0001391761,0.0001556299,0.0001121278,0.00001055645,0.00005008456,0.000002033895,0.0010514],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004911471,"threshold_uncertainty_score":0.01643056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04005756186369656,"score_gpt":0.3603240663664912,"score_spread":0.3202665045027946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}