{"id":"W4408688344","doi":"10.1084/jem.20231758","title":"Early Notch signals from fibroblastic reticular cells program effector CD8+ T cell differentiation","year":2025,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; Montreal Clinical Research Institute; Hôpital Maisonneuve-Rosemont","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; American Society for Transplantation and Cellular Therapy; Université de Montréal; University of Toronto","keywords":"Notch signaling pathway; Cell biology; Biology; Cellular differentiation; Effector; CD8; Reticular cell; Cytotoxic T cell; T cell; Immunology; Immune system; Signal transduction; Genetics; Gene; Spleen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009018609,0.0002139416,0.0001536115,0.0001822606,0.0001062162,0.0002790707,0.00009652627,0.0001937931,0.00123859],"category_scores_gemma":[0.00008398587,0.00009550585,0.0001297154,0.00008196637,0.0001312574,0.0001632239,0.0001887994,0.0004033125,0.0005975965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001425914,"about_ca_system_score_gemma":0.0001320571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002731424,"about_ca_topic_score_gemma":0.0007412544,"domain_scores_codex":[0.9999214,0.00001380695,0.000006487376,0.00001687963,0.00001794517,0.00002337765],"domain_scores_gemma":[0.9999349,0.00001055323,0.00001601112,0.000006530318,0.00001062002,0.00002147547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008234513,0.000006501321,0.0002939388,0.0000267886,0.000001478914,0.00005455219,0.00002313505,0.00003866888,0.9973041,0.0001185635,0.00002284405,0.002027097],"study_design_scores_gemma":[0.00001857312,0.0002639246,0.01119552,0.00001367168,0.00001156648,0.0002828134,0.0000856867,0.0007482769,0.9838319,0.000127533,0.003415012,0.00000548473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872907,0.00250955,0.005859966,0.000062231,0.00002114629,0.0000318616,0.000379904,0.0001107551,0.003733889],"genre_scores_gemma":[0.9936993,0.0006963147,0.002572842,0.00003786574,0.00001360841,0.00002128173,0.0002517123,0.00001685053,0.002690224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00123859,"threshold_uncertainty_score":0.004143476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00744672375166482,"score_gpt":0.2486960643477611,"score_spread":0.2412493405960962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}