{"id":"W4408695040","doi":"10.7554/elife.99160.2.sa0","title":"Author response: Pronounced expression of extracellular matrix proteoglycans regulated by Wnt pathway underlies the parallel evolution of lip hypertrophy in East African cichlids","year":2025,"lang":"en","type":"peer-review","venue":"","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Japan Society for the Promotion of Science","keywords":"Extracellular matrix; Expression (computer science); Wnt signaling pathway; Cell biology; Biology; Evolutionary biology; Signal transduction; Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001159209,0.0003907892,0.0006089719,0.0001862013,0.0000909483,0.0000148258,0.0003539662,0.0006855443,0.0001047179],"category_scores_gemma":[0.0004241073,0.0002679039,0.0002994373,0.0004479586,0.0002365459,0.000006049612,0.0001704428,0.0003036756,0.000001345493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001376726,"about_ca_system_score_gemma":0.0007788356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001830076,"about_ca_topic_score_gemma":0.00006617051,"domain_scores_codex":[0.996843,0.0008366643,0.0009445286,0.0006124243,0.0004849256,0.0002784275],"domain_scores_gemma":[0.9980493,0.00004752918,0.0006188524,0.0008108937,0.0004074429,0.00006598358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001787932,0.0001942816,0.00002163328,0.001816252,0.00006395767,8.382336e-7,0.00004610351,0.0002790987,0.7972869,0.0001777694,0.1971873,0.001137882],"study_design_scores_gemma":[0.001023563,0.0005625146,0.000232394,0.003075954,0.0001148998,0.000007464837,0.0002668987,0.000363098,0.1641877,0.000136541,0.829578,0.0004509669],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"other","genre_scores_codex":[0.1106036,0.5421358,0.1582071,0.1468164,0.003812929,0.03116057,0.003993882,0.0002646482,0.003005142],"genre_scores_gemma":[0.3243777,0.0007812473,0.001032148,0.00009590619,0.0001461219,0.0007382393,0.002352507,0.00005829755,0.6704178],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.6674127,"threshold_uncertainty_score":0.9999773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0140816521522695,"score_gpt":0.2689880002135159,"score_spread":0.2549063480612464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}