{"id":"W4408695499","doi":"10.1126/sciadv.adp9052","title":"Emergence of a senescent and inflammatory pulmonary CD4 <sup>+</sup> T cell population prior to lung allograft failure","year":2025,"lang":"en","type":"article","venue":"Science Advances","topic":"Transplantation: Methods and Outcomes","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; University Health Network","funders":"","keywords":"Lung; Lung transplantation; Medicine; Immunology; Bronchoalveolar lavage; Population; Pulmonary fibrosis; Fibrosis; Cytotoxic T cell; Inflammation; Idiopathic pulmonary fibrosis; Pathology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002245122,0.0001121371,0.0001882971,0.0004595428,0.0001675767,0.0003043277,0.0001064693,0.0001842508,0.001596947],"category_scores_gemma":[0.0002911279,0.00006749562,0.00008098393,0.0001483921,0.0002036993,0.000168431,0.0001787632,0.0002615452,0.000298725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001417579,"about_ca_system_score_gemma":0.0001388081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002647392,"about_ca_topic_score_gemma":0.0002865933,"domain_scores_codex":[0.9999256,0.00001294942,0.000006757705,0.00001937919,0.00001570882,0.00001956806],"domain_scores_gemma":[0.999779,0.00004244265,0.00004845535,0.00002073779,0.00003036119,0.00007888217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001249857,0.00009947465,0.1817009,0.00003647281,0.0000122973,0.0006501349,0.0001449114,0.000144212,0.7975821,0.0002564679,0.0001587943,0.01796439],"study_design_scores_gemma":[0.0000484906,0.001899921,0.7719391,0.00002527654,0.0000497092,0.005376277,0.0004799162,0.003081659,0.2132815,0.0005855889,0.003217098,0.00001554308],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978884,0.0003231462,0.0009870519,0.00002871619,0.000004641148,0.00001387671,0.00007913875,0.00002552211,0.00064952],"genre_scores_gemma":[0.998747,0.0001025904,0.0005624416,0.00003878921,0.00001151228,0.00001499041,0.0001463183,0.000004022129,0.0003722442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001596947,"threshold_uncertainty_score":0.005342364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007422619103810904,"score_gpt":0.3134820637094023,"score_spread":0.3060594446055914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}