{"id":"W4408714202","doi":"10.1177/07067437251328270","title":"The Safety and Efficacy of Microbial Ecosystem Therapeutic-2 in People With Major Depression – A Phase 2, Double-Blind, Placebo-Controlled Study: Clinical Results: Innocuité et efficacité du traitement de l'écosystème microbien (met–2) dans la dépression majeure – une étude de phase 2 à double insu contrölée par placebo : résultats cliniques","year":2025,"lang":"en","type":"article","venue":"The Canadian Journal of Psychiatry","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Centre for Addiction and Mental Health; Providence Health Care","funders":"Canadian Institutes of Health Research; Mitacs","keywords":"Placebo; Anhedonia; Mood; Adverse effect; Depression (economics); Anxiety; Medicine; Internal medicine; Psychiatry; Randomized controlled trial; Alternative medicine; Schizophrenia (object-oriented programming)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001664564,0.0005903646,0.001329782,0.0003097709,0.0003289293,0.0005237717,0.0004405348,0.001471969,0.002776262],"category_scores_gemma":[0.001150212,0.0004167461,0.0009740939,0.0001947446,0.0004605273,0.000442053,0.0002257611,0.001153382,0.0003373651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002829622,"about_ca_system_score_gemma":0.0004906766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004657848,"about_ca_topic_score_gemma":0.00120815,"domain_scores_codex":[0.9994701,0.0003089946,0.00005221734,0.00006456781,0.00006103539,0.0000431979],"domain_scores_gemma":[0.9994816,0.0001460461,0.0001387148,0.00004406629,0.00006968069,0.0001199322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8292292,0.04205106,0.003794451,0.002670993,0.002043911,0.0001271294,0.0002395476,0.0002681524,0.03310741,0.00009262619,0.0007512649,0.0856242],"study_design_scores_gemma":[0.5695046,0.4138463,0.01135525,0.00008770697,0.0007413634,0.00008955479,0.00006148358,0.0003226768,0.002875765,0.00005900634,0.001035264,0.00002104291],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892437,0.006582965,0.0005088682,0.0002553816,0.0001561499,0.002123611,0.0003620213,0.00004023911,0.000727049],"genre_scores_gemma":[0.9910323,0.003355341,0.001323357,0.0005501827,0.0002868918,0.001619425,0.0003276961,0.000008289576,0.001496642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002776262,"threshold_uncertainty_score":0.009287536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01414903383889145,"score_gpt":0.3318665911033519,"score_spread":0.3177175572644604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}