{"id":"W4408718207","doi":"10.1126/sciadv.adn8402","title":"AMPK-dependent Parkin activation suppresses macrophage antigen presentation to promote tumor progression","year":2025,"lang":"en","type":"article","venue":"Science Advances","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"","keywords":"Parkin; Immune system; Antigen presentation; Cancer research; Biology; Autophagy; Tumor microenvironment; Ubiquitin ligase; Macrophage; Immunotherapy; Cross-presentation; Immunology; T cell; Cell biology; Ubiquitin; Medicine; Apoptosis; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001494386,0.0001788135,0.0002457963,0.0001664989,0.00009560298,0.0002677071,0.000103442,0.0001600607,0.001079632],"category_scores_gemma":[0.0000851302,0.0000961113,0.0001459828,0.00008153519,0.0001899098,0.0001540552,0.0001538167,0.0005711023,0.0002602234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001227218,"about_ca_system_score_gemma":0.0001791716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001222855,"about_ca_topic_score_gemma":0.0003045276,"domain_scores_codex":[0.999884,0.00002211684,0.0000119418,0.00002300924,0.0000209586,0.00003791571],"domain_scores_gemma":[0.9999176,0.00001023019,0.00002364056,0.000009755156,0.000006205843,0.00003263017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000363742,0.00006992393,0.0002899489,0.00003950077,0.000004997383,0.00003617346,0.00001144713,0.0001091094,0.9968125,0.0001876005,0.0001104691,0.001964536],"study_design_scores_gemma":[0.0000643985,0.000643105,0.005641874,0.000009448023,0.00001780854,0.000279745,0.000055482,0.00212991,0.985557,0.0002277013,0.005368825,0.000004699775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942545,0.001493011,0.002096612,0.0002004144,0.00005126644,0.00001691741,0.0002316195,0.00008575391,0.001569847],"genre_scores_gemma":[0.9971654,0.0003772848,0.0005767268,0.00006619116,0.000008323895,0.00001649095,0.000128025,0.00001109747,0.001650368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001079632,"threshold_uncertainty_score":0.003611684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008272460053247074,"score_gpt":0.3242998458040193,"score_spread":0.3160273857507723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}