{"id":"W4408718207","doi":"10.1126/sciadv.adn8402","title":"AMPK-dependent Parkin activation suppresses macrophage antigen presentation to promote tumor progression","year":2025,"lang":"en","type":"article","venue":"Science Advances","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"","keywords":"Parkin; Immune system; Antigen presentation; Cancer research; Biology; Autophagy; Tumor microenvironment; Ubiquitin ligase; Macrophage; Immunotherapy; Cross-presentation; Immunology; T cell; Cell biology; Ubiquitin; Medicine; Apoptosis; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004082574,0.0001400445,0.0001487708,0.0002374723,0.0005079653,0.0000686498,0.0005639598,0.00005385488,0.0001700937],"category_scores_gemma":[0.000267061,0.0001163069,0.00002803665,0.0008380119,0.0005268187,0.0008286136,0.0002211647,0.0001520852,0.0001603576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001097526,"about_ca_system_score_gemma":0.0002195053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002755848,"about_ca_topic_score_gemma":0.00001094969,"domain_scores_codex":[0.9986334,0.0000687268,0.0002296468,0.0005125833,0.0001314863,0.0004241538],"domain_scores_gemma":[0.9993145,0.00006003239,0.0001191195,0.0003235434,0.0001601703,0.00002259156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000905896,0.00005415409,0.002229165,0.00002594907,0.000008735982,0.000001599862,0.0002900561,0.0001236524,0.902038,0.0001465748,0.0004317061,0.09455983],"study_design_scores_gemma":[0.0002994772,0.00008297133,0.008097684,0.0001385987,0.000006092443,0.000003805934,0.0002248421,0.000005041382,0.928171,0.000549368,0.06229971,0.0001213676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848949,0.004756052,0.001962391,0.0007217497,0.002933813,0.0009274388,0.000008782818,0.0001173815,0.003677519],"genre_scores_gemma":[0.9947272,0.00005797729,0.001441787,0.0002289323,0.00002177846,0.0001181105,0.00001350056,0.00000724051,0.003383468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09443847,"threshold_uncertainty_score":0.4742856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008272460053247074,"score_gpt":0.3242998458040193,"score_spread":0.3160273857507723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}