{"id":"W4408721267","doi":"10.1117/12.3048784","title":"Towards an early diagnostic for Alzheimer's disease through multimodal spectroscopic evaluation of buccal cells","year":2025,"lang":"en","type":"article","venue":"","topic":"Spectroscopy Techniques in Biomedical and Chemical Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Buccal administration; Computer science; Disease; Medicine; Dentistry; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000714336,0.0003729009,0.0003726326,0.0009057689,0.000230696,0.0006532805,0.0003845996,0.0008730129,0.00122348],"category_scores_gemma":[0.0005029457,0.0002417949,0.0002318108,0.0003234692,0.0002821363,0.0005115448,0.0004143151,0.0005730832,0.0004900309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001429181,"about_ca_system_score_gemma":0.0001372829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004854533,"about_ca_topic_score_gemma":0.001039525,"domain_scores_codex":[0.9997857,0.00006395747,0.00000967624,0.00005879067,0.0000528032,0.00002912818],"domain_scores_gemma":[0.9998573,0.00003954151,0.00003170896,0.00001316549,0.00004511663,0.00001306367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000112779,0.00003539499,0.002978382,0.0001003337,0.0000122676,0.00007466198,0.00006889213,0.00007611424,0.9836511,0.0001146024,0.0000991033,0.01267633],"study_design_scores_gemma":[0.00002171911,0.0005890275,0.03145672,0.00007929925,0.0001875561,0.002180009,0.0005347218,0.009072326,0.9508528,0.0006424781,0.004333176,0.00004999615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8457177,0.01354557,0.1335442,0.0005868356,0.0001024299,0.0002211377,0.0005180398,0.000609128,0.00515488],"genre_scores_gemma":[0.822301,0.005662848,0.1678502,0.0004184699,0.00004793484,0.0002030393,0.0002510809,0.00004883498,0.003216637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00122348,"threshold_uncertainty_score":0.004092932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02796578237530756,"score_gpt":0.398640396364613,"score_spread":0.3706746139893055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}