{"id":"W4408721878","doi":"10.1016/j.ymthe.2025.03.006","title":"From cortex to medulla: Navigating the thymic landscape of T cell education","year":2025,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Engineering and Physical Sciences Research Council; Vlaamse regering; Universiteit Gent; Fonds Wetenschappelijk Onderzoek; Wellcome Trust; Canadian Institute for Advanced Research","keywords":"Medulla; Cortex (anatomy); Biology; Neuroscience; Cell biology; Anatomy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002859754,0.0002089881,0.0003867314,0.0003191291,0.0005437373,0.002347908,0.0004069708,0.0004293525,0.002478533],"category_scores_gemma":[0.0006119897,0.0001912848,0.0001763733,0.0002395132,0.0007786126,0.001437028,0.0006897986,0.001328435,0.0005012636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007259685,"about_ca_system_score_gemma":0.001049836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001795317,"about_ca_topic_score_gemma":0.005216341,"domain_scores_codex":[0.9998335,0.00004374822,0.000004614376,0.0000385074,0.00003852378,0.00004116473],"domain_scores_gemma":[0.9997374,0.00007582294,0.00003762044,0.00002468621,0.0000427751,0.00008156871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004049295,0.00004722911,0.005043766,0.0002953183,0.00002697673,0.0003366467,0.0009459074,0.00327171,0.8543839,0.01805207,0.001938633,0.1152528],"study_design_scores_gemma":[0.0001367199,0.000952446,0.102786,0.0003392089,0.0002047414,0.001394971,0.006036079,0.04081469,0.6922407,0.06506008,0.08989946,0.0001350013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8362968,0.01584595,0.1116468,0.005903913,0.0004056224,0.00005883722,0.00050923,0.0006961317,0.02863668],"genre_scores_gemma":[0.9833055,0.002566556,0.008976335,0.0004060706,0.00006550606,0.00002745701,0.00005465272,0.0001129731,0.004484791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002478533,"threshold_uncertainty_score":0.008291543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005050236654867624,"score_gpt":0.2501109744243121,"score_spread":0.2450607377694445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}