{"id":"W4408727962","doi":"10.1038/s41598-025-93899-1","title":"Metatranscriptomic analysis reveals gut microbiome bacterial genes in pyruvate and amino acid metabolism associated with hyperuricemia and gout in humans","year":2025,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Gout, Hyperuricemia, Uric Acid","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Consejo Nacional de Ciencia y Tecnología","keywords":"Hyperuricemia; Gout; Uric acid; Microbiome; Gut microbiome; Amino acid metabolism; Metabolism; Biology; Bioinformatics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000360692,0.0003709898,0.00069317,0.001397097,0.0002789813,0.0006488186,0.0001519811,0.0003570964,0.0009220185],"category_scores_gemma":[0.0006037321,0.0002223089,0.0008001538,0.001151612,0.0001644487,0.0001813417,0.0003423961,0.0003920713,0.0002124911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001872239,"about_ca_system_score_gemma":0.0001826466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00112717,"about_ca_topic_score_gemma":0.001376409,"domain_scores_codex":[0.9996691,0.00006316617,0.00001977598,0.0001128147,0.00007730709,0.00005780919],"domain_scores_gemma":[0.9997136,0.00006650122,0.00008598882,0.00003430634,0.00004925633,0.00005028409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002157382,0.0001170806,0.2089193,0.0002137581,0.0005741408,0.0002842017,0.0004152808,0.0005513826,0.7708976,0.0001331008,0.0001846351,0.01555198],"study_design_scores_gemma":[0.0000212808,0.000515078,0.9682415,0.00003497713,0.0004331564,0.0007748095,0.0004787774,0.004433771,0.02357854,0.0003410186,0.001119978,0.00002712147],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994296,0.001132885,0.00235436,0.00006237996,0.00001258291,0.00002587362,0.001792507,0.00002676246,0.0002967063],"genre_scores_gemma":[0.9933159,0.0005002726,0.003217033,0.00009049635,0.00001845925,0.00003857143,0.002306761,0.00001738023,0.0004950278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001397097,"threshold_uncertainty_score":0.003084481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008483059463535033,"score_gpt":0.2405457254365942,"score_spread":0.2320626659730592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}