{"id":"W4408735191","doi":"10.1245/s10434-025-17156-5","title":"Recurrence-Free Survival as a Surrogate for Overall Survival Among Patients with Intrahepatic Cholangiocarcinoma Following Upfront Surgery: An International Multi-institutional Analysis","year":2025,"lang":"en","type":"article","venue":"Annals of Surgical Oncology","topic":"Cholangiocarcinoma and Gallbladder Cancer Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Medicine; Concordance; Surrogate endpoint; Surgical oncology; Clinical endpoint; Intrahepatic Cholangiocarcinoma; Internal medicine; Overall survival; Surgery; Survival analysis; Hepatectomy; Oncology; Resection; Gastroenterology; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00262483,0.0002816294,0.0003699224,0.001829537,0.0002317233,0.0006527656,0.0004266788,0.0001777928,0.0005606103],"category_scores_gemma":[0.004394038,0.0001532637,0.000785099,0.002333569,0.0002858587,0.0004268676,0.0007075462,0.0003101004,0.00009130722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004303146,"about_ca_system_score_gemma":0.0004179195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003180702,"about_ca_topic_score_gemma":0.003664528,"domain_scores_codex":[0.9989958,0.0003742051,0.0001725675,0.0001815729,0.0001887401,0.00008707854],"domain_scores_gemma":[0.9944326,0.00101824,0.003141727,0.000676763,0.0004136141,0.0003170413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001289307,0.000007578658,0.9984811,0.000008087968,0.00009517291,0.00002558314,0.00002508861,0.0001350106,0.00009317815,0.00001292536,0.00004515337,0.0009421238],"study_design_scores_gemma":[0.000007710715,0.00007416734,0.9986717,0.000005022849,0.00009122286,0.0001761028,0.00006631152,0.0006379202,0.0001061837,0.00001937731,0.0001390687,0.000005298997],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998833,0.0001953923,0.0003066925,0.00001494149,0.000001867335,0.000008367232,0.0004651358,0.000005383898,0.0001691881],"genre_scores_gemma":[0.9987811,0.00004781366,0.0001803887,0.000007006487,0.000004649485,0.00001079893,0.0009426119,0.000002070361,0.00002340923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003180702,"threshold_uncertainty_score":0.01388156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0608006393738792,"score_gpt":0.3634724717965439,"score_spread":0.3026718324226647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}