{"id":"W4408743974","doi":"10.1007/s10689-025-00455-x","title":"Azacitidine and venetoclax for the treatment of AML arising from an underlying telomere biology disorder","year":2025,"lang":"en","type":"letter","venue":"Familial Cancer","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; Sunnybrook Hospital; University of Toronto","funders":"","keywords":"Venetoclax; Telomere; Azacitidine; Human genetics; Medicine; Biology; Genetics; Leukemia; Immunology; DNA methylation; Chronic lymphocytic leukemia; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004528579,0.0002822778,0.0005390155,0.0004312425,0.001430388,0.0006389648,0.0004408659,0.01131221,0.001837597],"category_scores_gemma":[0.003025147,0.0002010095,0.0005126629,0.000290457,0.0008347864,0.0006914404,0.0003068153,0.006605899,0.0007255524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001498792,"about_ca_system_score_gemma":0.000960805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002377257,"about_ca_topic_score_gemma":0.007758212,"domain_scores_codex":[0.9996434,0.0001337275,0.00003498552,0.00003696892,0.00009288458,0.0000579474],"domain_scores_gemma":[0.9993677,0.0003848338,0.00004751889,0.00001791733,0.00003891253,0.0001431566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"case_report","study_design_scores_codex":[0.00116208,0.0002879854,0.01510894,0.0002213778,0.0001273478,0.2820846,0.0004587238,0.00102992,0.003573531,0.01790792,0.5937458,0.08429185],"study_design_scores_gemma":[0.000737422,0.0006915689,0.01599061,0.0006358067,0.0001556426,0.2333836,0.0005916629,0.004113646,0.001871866,0.02402541,0.7177153,0.00008761835],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.02817145,0.01801283,0.0004911298,0.9108578,0.0130542,0.00003949417,0.0001030526,0.00006229846,0.02920766],"genre_scores_gemma":[0.3059777,0.01721461,0.001989424,0.5557387,0.08455732,0.0000948133,0.0001615088,0.00005228084,0.0342137],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01131221,"threshold_uncertainty_score":0.01087451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06226947531547121,"score_gpt":0.3677120936838942,"score_spread":0.305442618368423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}