{"id":"W4408746159","doi":"10.1093/braincomms/fcaf117","title":"Enduring differential patterns of neuronal loss and myelination along 6-month pulsatile gonadotropin-releasing hormone therapy in individuals with Down syndrome","year":2025,"lang":"en","type":"article","venue":"Brain Communications","topic":"Down syndrome and intellectual disability research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Down syndrome; White matter; Brain size; Medicine; Diffusion MRI; Magnetic resonance imaging; Internal medicine; Brain morphometry; Grey matter; Turner syndrome; Cognition; Neuroscience; Endocrinology; Psychology; Psychiatry; Radiology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001621917,0.0001414452,0.0002270499,0.0004051186,0.0001397692,0.0001826318,0.00008881849,0.00019286,0.0005162514],"category_scores_gemma":[0.0004735464,0.00009098823,0.0001273777,0.0001947416,0.0001619718,0.0001238092,0.0001645119,0.000177485,0.00007455332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001352817,"about_ca_system_score_gemma":0.00007574713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001362168,"about_ca_topic_score_gemma":0.00194646,"domain_scores_codex":[0.9999136,0.00001840269,0.000009792803,0.00002647966,0.00001593866,0.00001581782],"domain_scores_gemma":[0.9997752,0.00003834626,0.0001019666,0.00001630607,0.00002694787,0.0000412044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004129821,0.0001696136,0.7930565,0.00005688126,0.0001429587,0.001779073,0.0008439461,0.0001328095,0.1818254,0.00003237778,0.0001108657,0.01771976],"study_design_scores_gemma":[0.000003718856,0.0002996455,0.9976642,0.000001448129,0.00001421162,0.0004236646,0.0001084554,0.000032671,0.001376291,0.000008061746,0.00006545761,0.000002204392],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997589,0.00007304589,0.0000400112,0.000006999273,9.804777e-7,0.000001741129,0.00004860809,0.000001632994,0.00006809398],"genre_scores_gemma":[0.9996566,0.00004666205,0.0000663199,0.000007494785,0.000001377869,0.000003729753,0.00007727162,0.000001059154,0.0001394219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001362168,"threshold_uncertainty_score":0.002708435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03243826866383956,"score_gpt":0.3230436790728964,"score_spread":0.2906054104090569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}