{"id":"W4408766995","doi":"10.1038/s41467-025-58083-z","title":"Mimicry of molecular glues using dual covalent chimeras","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre; McMaster University","funders":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Ternary complex; Covalent bond; Chemistry; Biophysics; Molecular mimicry; Chimera (genetics); Bioorthogonal chemistry; Small molecule; Biochemistry; Biology; Combinatorial chemistry; Click chemistry; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002657682,0.0004329909,0.0002176992,0.0002016211,0.0001316125,0.0004421692,0.0004069801,0.0005040281,0.001117169],"category_scores_gemma":[0.0002879614,0.0002163455,0.000292084,0.000164377,0.0003580255,0.0004483878,0.0005655742,0.0006880597,0.0003244405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000408449,"about_ca_system_score_gemma":0.0001681543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002425245,"about_ca_topic_score_gemma":0.0003637082,"domain_scores_codex":[0.999733,0.00005728409,0.00002033561,0.00007630239,0.00006175427,0.00005121684],"domain_scores_gemma":[0.9998218,0.00002782008,0.00007538289,0.00003159814,0.00001322503,0.00003019766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004099203,0.00001342562,0.00009335061,0.00004128782,0.000008970777,0.00008513112,0.00002079042,0.0003567121,0.9957538,0.001265044,0.00005387828,0.002266737],"study_design_scores_gemma":[0.00000435225,0.000079151,0.0001255762,0.000001908357,0.000006935589,0.000134591,0.000005434241,0.001142783,0.9960508,0.00005559713,0.002388869,0.000004028622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9264118,0.00134639,0.0659854,0.0002135156,0.00007253024,0.00008629079,0.0001511017,0.0005270928,0.0052059],"genre_scores_gemma":[0.9811606,0.0004652234,0.01542999,0.00006641903,0.000007231005,0.0000481328,0.0001045401,0.00004063662,0.002677343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001117169,"threshold_uncertainty_score":0.00373733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02033809544794964,"score_gpt":0.3387932405401149,"score_spread":0.3184551450921653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}