{"id":"W4408766995","doi":"10.1038/s41467-025-58083-z","title":"Mimicry of molecular glues using dual covalent chimeras","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre; McMaster University","funders":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Ternary complex; Covalent bond; Chemistry; Biophysics; Molecular mimicry; Chimera (genetics); Bioorthogonal chemistry; Small molecule; Biochemistry; Biology; Combinatorial chemistry; Click chemistry; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006397314,0.0001071645,0.0001437878,0.00004089212,0.0001961495,0.00001385674,0.0007854074,0.0002544463,0.00009253815],"category_scores_gemma":[0.0001072017,0.0001187728,0.00009874621,0.00030444,0.0001762917,0.00003153315,0.0003594601,0.0006259432,0.000003261649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004914955,"about_ca_system_score_gemma":0.00009401724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002060132,"about_ca_topic_score_gemma":0.00001224478,"domain_scores_codex":[0.9993525,0.00001876982,0.0002593767,0.0001576005,0.00009852423,0.0001132934],"domain_scores_gemma":[0.997569,0.000180825,0.0001120243,0.001968021,0.0001362761,0.00003391719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005692831,0.0001881595,0.0006087864,0.0000570489,0.00006602066,3.07494e-7,0.00004306263,0.00002700317,0.9783493,0.01923007,0.001023985,0.0004006231],"study_design_scores_gemma":[0.0001915754,0.000001222733,0.0003244507,0.00009914587,0.00008476181,0.000004604884,0.000107716,0.0004936656,0.9527918,0.001141767,0.0446532,0.0001061002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9153392,0.01211962,0.0002603432,0.003783151,0.00003934261,0.00009544364,0.0001328635,0.00009327813,0.06813679],"genre_scores_gemma":[0.9927741,0.0002877354,0.005997101,0.0002143312,0.00001929774,0.00002901983,0.0001779792,0.000009908885,0.0004904923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07743496,"threshold_uncertainty_score":0.4843413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02033809544794964,"score_gpt":0.3387932405401149,"score_spread":0.3184551450921653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}