{"id":"W4408773262","doi":"10.58931/cct.2025.114","title":"PCSK9 Targeted Therapy to Lower Cholesterol and Reduce Cardiovascular Events","year":2025,"lang":"en","type":"article","venue":"Canadian Cardiology Today","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; University of Toronto; St. Michael's Hospital","funders":"","keywords":"Evolocumab; Alirocumab; PCSK9; Ezetimibe; Proprotein convertase; Medicine; Kexin; Statin; Disease; Clinical trial; Cholesterol; Internal medicine; Pharmacology; Lipoprotein; LDL receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008338005,0.000254539,0.0009293598,0.0004022754,0.0001829271,0.00001626302,0.0001448792,0.0003139482,0.00003585132],"category_scores_gemma":[0.0001213854,0.0002311855,0.0006003595,0.0004031396,0.00008483879,0.00004174055,0.00004331065,0.0003100547,0.00005295543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003566457,"about_ca_system_score_gemma":0.001044714,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02636348,"about_ca_topic_score_gemma":0.003697226,"domain_scores_codex":[0.9979688,0.0002436528,0.0002557972,0.0006289298,0.0002267272,0.0006761132],"domain_scores_gemma":[0.9977491,0.00002116883,0.00002140701,0.001140344,0.0001516593,0.0009163466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000471632,0.00005572468,0.09916876,0.0002737583,0.01464212,0.00167302,0.0004973399,0.0003110632,0.002391481,0.0006435952,0.04270399,0.8371675],"study_design_scores_gemma":[0.00168607,0.0001637226,0.3394967,0.00006964216,0.0002043011,0.0002518065,0.00005206354,0.000003339792,0.0004823539,0.00006206482,0.6573399,0.0001880027],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.955299,0.02174671,0.0004174859,0.006395655,0.001424782,0.001775276,0.00004756725,0.00007478487,0.01281873],"genre_scores_gemma":[0.9881116,0.0007342474,0.0001537557,0.008850693,0.0004948338,0.0001636046,0.00003077828,0.0000342296,0.001426257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8369795,"threshold_uncertainty_score":0.9801201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01286534570143037,"score_gpt":0.2567634145575199,"score_spread":0.2438980688560896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}