{"id":"W4408773262","doi":"10.58931/cct.2025.114","title":"PCSK9 Targeted Therapy to Lower Cholesterol and Reduce Cardiovascular Events","year":2025,"lang":"en","type":"article","venue":"Canadian Cardiology Today","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; University of Toronto; St. Michael's Hospital","funders":"","keywords":"Evolocumab; Alirocumab; PCSK9; Ezetimibe; Proprotein convertase; Medicine; Kexin; Statin; Disease; Clinical trial; Cholesterol; Internal medicine; Pharmacology; Lipoprotein; LDL receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003541985,0.0002809689,0.0003542359,0.0004668142,0.0003737463,0.0005808522,0.0002569484,0.0004277562,0.005030325],"category_scores_gemma":[0.0006942949,0.0000671478,0.000308648,0.0003240732,0.0003006989,0.0002518006,0.0002960307,0.001081467,0.001121121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001754189,"about_ca_system_score_gemma":0.002231736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02996104,"about_ca_topic_score_gemma":0.0823139,"domain_scores_codex":[0.999763,0.00003083037,0.00001289068,0.00002579265,0.0001296772,0.00003784307],"domain_scores_gemma":[0.999811,0.00003202684,0.0000264825,0.000005835041,0.00008547113,0.00003921413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005664462,0.0002418038,0.003141084,0.001414876,0.0002139719,0.0003821937,0.0001324871,0.0003871782,0.01124747,0.008802308,0.1357798,0.8376904],"study_design_scores_gemma":[0.0007567937,0.0007696034,0.0226602,0.002211474,0.0003651734,0.002037972,0.0002067336,0.0007511099,0.008338354,0.004197605,0.9576597,0.00004516783],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"editorial","genre_scores_codex":[0.02972793,0.8306977,0.00419642,0.04675322,0.003431599,0.0001139143,0.0006174548,0.000428824,0.08403295],"genre_scores_gemma":[0.2090871,0.720556,0.006892974,0.01774118,0.002952554,0.00007181027,0.0005906537,0.00007532939,0.04203246],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.02996104,"threshold_uncertainty_score":0.05957329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01286534570143037,"score_gpt":0.2567634145575199,"score_spread":0.2438980688560896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}