{"id":"W4408776901","doi":"10.1016/j.labinv.2024.103244","title":"1010 Methylation Profiling of Small Cell Carcinoma Hypercalcemic Type (SCCOHT) Identifies Three Groups with Distinct Clinical and Morphological Characteristics","year":2025,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Centre for Applied Research in Cancer Control; BC Cancer Foundation; BC Cancer Agency; University of British Columbia; McGill University; McGill University Health Centre","funders":"","keywords":"Biology; Methylation; DNA methylation; Carcinoma; Small-cell carcinoma; Gene expression profiling; Profiling (computer programming); Pathology; Computational biology; Cancer research; Genetics; Gene; Medicine; Gene expression; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002894433,0.0001141476,0.0001658947,0.0000311386,0.00005742835,0.0000197433,0.00007466007,0.0001747512,0.000003184273],"category_scores_gemma":[0.0001850894,0.00009673918,0.00002484553,0.0001624854,0.000247268,0.000006440743,0.00004656285,0.0001144771,0.000001075592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001006674,"about_ca_system_score_gemma":0.0001941212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001344781,"about_ca_topic_score_gemma":0.00003405887,"domain_scores_codex":[0.9991371,0.00008882766,0.0003197735,0.0002771839,0.00007906817,0.00009802223],"domain_scores_gemma":[0.9992981,0.00002982624,0.0001511849,0.0002058188,0.0002668813,0.00004818632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000765725,0.00001779131,0.3970627,0.00008403736,0.00001411829,0.000001188446,0.00002254194,0.00001907144,0.6021904,0.0000880685,0.00004079512,0.0003826342],"study_design_scores_gemma":[0.0005853712,0.0002790901,0.414684,0.00004982068,0.00008626855,0.000002360427,0.00007528852,0.001934951,0.5815074,0.0005430089,0.00009012791,0.0001622915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961659,0.0004842076,0.002874905,0.00004181558,0.0001593556,0.0001535684,0.00002591161,0.00001469288,0.0000796895],"genre_scores_gemma":[0.9962417,0.00004091009,0.003230954,0.0001331883,0.00009714862,0.0000102764,0.0001960395,0.00001049486,0.00003925909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02068299,"threshold_uncertainty_score":0.3944909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02224535861089342,"score_gpt":0.2662393457275038,"score_spread":0.2439939871166104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}