{"id":"W4408777978","doi":"10.1016/j.labinv.2024.104078","title":"1832 Subtyping Breast Carcinoma: Harmonization of Gene Expression Profiling with Immunohistochemistry (IHC) Depends on Adjustment of Analytical Sensitivity with Diagnostic Cut-off of for Estrogen Receptor IHC","year":2025,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Gene expression and cancer classification","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Saskatchewan Health Authority","funders":"","keywords":"Subtyping; Immunohistochemistry; Breast carcinoma; Estrogen receptor; Pathology; Breast cancer; Biology; Gene expression profiling; Gene expression; Medicine; Gene; Cancer; Genetics; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00588924,0.0003230032,0.0006530607,0.001559234,0.000306541,0.0009305523,0.000385342,0.0002705921,0.000751272],"category_scores_gemma":[0.005278206,0.0002119207,0.000307881,0.001090406,0.0004661115,0.0003821992,0.0006139091,0.0003315472,0.0005966705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002491498,"about_ca_system_score_gemma":0.0003573133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006453693,"about_ca_topic_score_gemma":0.001076338,"domain_scores_codex":[0.9968688,0.001546194,0.0003446468,0.0004065808,0.0006840178,0.0001497628],"domain_scores_gemma":[0.9971795,0.001300013,0.0003168863,0.0005348591,0.0005869074,0.00008181659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009637446,0.0001447084,0.3675348,0.0002374645,0.0001899196,0.000254254,0.0003826243,0.0008866213,0.5080886,0.000543147,0.0008833922,0.1198905],"study_design_scores_gemma":[0.00001957734,0.0004343592,0.8196141,0.00003719154,0.0001853771,0.001757537,0.000326013,0.005785394,0.1661464,0.0009163615,0.004751659,0.00002609948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.90651,0.003827597,0.08122236,0.0005092492,0.00007970693,0.0002001269,0.0006073,0.0004648745,0.006578796],"genre_scores_gemma":[0.9707007,0.0006370574,0.02688891,0.0001730276,0.00004897438,0.0001035209,0.0005156411,0.0001185929,0.0008136149],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.00588924,"threshold_uncertainty_score":0.03114563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009101850082078117,"score_gpt":0.2434483092580736,"score_spread":0.2343464591759955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}