{"id":"W4408777978","doi":"10.1016/j.labinv.2024.104078","title":"1832 Subtyping Breast Carcinoma: Harmonization of Gene Expression Profiling with Immunohistochemistry (IHC) Depends on Adjustment of Analytical Sensitivity with Diagnostic Cut-off of for Estrogen Receptor IHC","year":2025,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Gene expression and cancer classification","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Saskatchewan Health Authority","funders":"","keywords":"Subtyping; Immunohistochemistry; Breast carcinoma; Estrogen receptor; Pathology; Breast cancer; Biology; Gene expression profiling; Gene expression; Medicine; Gene; Cancer; Genetics; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001804507,0.0001528558,0.0002063719,0.00007844082,0.00005366176,0.000005828566,0.00008041164,0.0001373222,0.000003016664],"category_scores_gemma":[0.0001721683,0.0001323558,0.00003960265,0.0003107433,0.0001594874,0.00001223474,0.000022532,0.00006587438,1.750911e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005171768,"about_ca_system_score_gemma":0.000479088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007587221,"about_ca_topic_score_gemma":0.000001982758,"domain_scores_codex":[0.9989541,0.0000917976,0.0003257001,0.0003225021,0.0001860641,0.00011979],"domain_scores_gemma":[0.9984968,0.00005348926,0.0003846714,0.0003426684,0.0006659136,0.00005641235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005742735,0.000089606,0.03331013,0.000252792,0.00004488552,2.607259e-7,0.0000577911,0.0007021282,0.9642251,0.0002135101,0.000206401,0.0003231007],"study_design_scores_gemma":[0.0008339107,0.0002682801,0.01548167,0.0003336793,0.00007792388,0.000001474653,0.0001968108,0.0004753389,0.982149,0.00001205479,0.00004929857,0.0001205486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882869,0.0004276761,0.01052059,0.00006730322,0.00005594941,0.0004034865,0.0001828333,0.000008671046,0.00004665675],"genre_scores_gemma":[0.9938229,0.00002780101,0.005247612,0.00004399984,0.00004706064,0.00007593739,0.0006835364,0.00001748744,0.00003365609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01792389,"threshold_uncertainty_score":0.5397314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009101850082078117,"score_gpt":0.2434483092580736,"score_spread":0.2343464591759955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}