{"id":"W4408778571","doi":"10.1001/jamaneurol.2025.0241","title":"Reldesemtiv in Amyotrophic Lateral Sclerosis","year":2025,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; University of Alberta; Montreal Neurological Institute and Hospital","funders":"National Center for Advancing Translational Sciences","keywords":"Amyotrophic lateral sclerosis; Medicine; Placebo; Interim analysis; Riluzole; Physical therapy; Clinical endpoint; Clinical trial; Adverse effect; Randomized controlled trial; Rating scale; Internal medicine; Disease; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002530177,0.000164757,0.0003869873,0.0004543523,0.00005349607,0.00003097685,0.0002081718,0.0003380459,0.0003279462],"category_scores_gemma":[0.0003034432,0.0001409005,0.00009161636,0.0007027615,0.0001727177,0.00010127,0.0002065703,0.001208921,0.0001800653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007101799,"about_ca_system_score_gemma":0.0001120532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002704382,"about_ca_topic_score_gemma":0.00005569967,"domain_scores_codex":[0.9981423,0.000223276,0.0003446827,0.0004816677,0.0002320248,0.0005760179],"domain_scores_gemma":[0.9991667,0.0001498721,0.00003843395,0.0004499989,0.00007712079,0.000117924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004298949,0.0005428261,0.7343121,0.0001297625,0.00009183445,0.001239015,0.0001484781,0.00006517291,0.1842579,0.002887499,0.04033532,0.03169115],"study_design_scores_gemma":[0.002953252,0.0004995012,0.9766751,0.00007476292,0.00001258556,0.00003902319,0.000001922191,0.0008945221,0.0004585434,0.0007759214,0.017525,0.00008989671],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8629837,0.0001274843,0.00001472497,0.130172,0.0002152247,0.000325068,0.00000204239,0.00007688769,0.006082851],"genre_scores_gemma":[0.9641225,0.0002755427,0.00008889317,0.03329849,0.0001025957,0.00005995971,0.000007531865,0.0000225593,0.002021981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.242363,"threshold_uncertainty_score":0.5745757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02735648948666966,"score_gpt":0.2989608560038986,"score_spread":0.271604366517229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}