{"id":"W4408778571","doi":"10.1001/jamaneurol.2025.0241","title":"Reldesemtiv in Amyotrophic Lateral Sclerosis","year":2025,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; University of Alberta; Montreal Neurological Institute and Hospital","funders":"National Center for Advancing Translational Sciences","keywords":"Amyotrophic lateral sclerosis; Medicine; Placebo; Interim analysis; Riluzole; Physical therapy; Clinical endpoint; Clinical trial; Adverse effect; Randomized controlled trial; Rating scale; Internal medicine; Disease; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001493114,0.0004600918,0.0009753912,0.0002279294,0.0001717287,0.0003959496,0.0003863268,0.0006757466,0.002828601],"category_scores_gemma":[0.0009957099,0.0001562005,0.0006366033,0.000242401,0.000421754,0.0003194526,0.0002093026,0.001074838,0.0002616991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002473755,"about_ca_system_score_gemma":0.0004434663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003315355,"about_ca_topic_score_gemma":0.001107384,"domain_scores_codex":[0.9996012,0.000251228,0.00003996217,0.00003562794,0.00004503836,0.00002705059],"domain_scores_gemma":[0.9995505,0.0001753367,0.0001587784,0.00001730854,0.00002972456,0.00006831608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.4294558,0.008514091,0.005914417,0.01129862,0.001464454,0.0004211619,0.0002104212,0.001139201,0.01611658,0.000756464,0.003469785,0.5212389],"study_design_scores_gemma":[0.5588594,0.3900142,0.02700897,0.00131908,0.001631548,0.0008269529,0.0001766072,0.001201056,0.004588082,0.0007677017,0.01357313,0.00003334184],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8762757,0.1153418,0.0008151475,0.001469803,0.0005359495,0.001139396,0.0003142383,0.0001314191,0.003976483],"genre_scores_gemma":[0.9682536,0.02473064,0.001601418,0.0009630516,0.0005943943,0.001113095,0.0003816766,0.00001005925,0.002351996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002828601,"threshold_uncertainty_score":0.009462595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02735648948666966,"score_gpt":0.2989608560038986,"score_spread":0.271604366517229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}