{"id":"W4408784822","doi":"10.1158/0008-5472.can-24-2266","title":"An Anti-EGFR Antibody–Drug Radioconjugate Labeled with Actinium-225 Elicits Durable Antitumor Responses in KRAS- and BRAF-Mutant Colorectal Cancer","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal University Hospital; University of Saskatchewan; Saskatoon Medical Imaging; Université Laval; Centre hospitalier de l'Université Laval; Saskatchewan Health Authority; Hôtel-Dieu de Québec","funders":"Canadian Institutes of Health Research","keywords":"Nimotuzumab; KRAS; Panitumumab; Medicine; Cetuximab; Colorectal cancer; Antibody-drug conjugate; Cancer research; Epidermal growth factor receptor; Cancer; Antibody; Monoclonal antibody; Pharmacology; Internal medicine; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009260127,0.0002734066,0.0002080181,0.0001391213,0.00007453049,0.0001595875,0.0001229031,0.0001625985,0.0003925006],"category_scores_gemma":[0.0000488507,0.0001102303,0.0001545255,0.00009114376,0.0001013297,0.0001004284,0.00009366655,0.0002588291,0.000127362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002631349,"about_ca_system_score_gemma":0.0001297462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006618056,"about_ca_topic_score_gemma":0.0009762936,"domain_scores_codex":[0.9999274,0.0000128733,0.000003992772,0.00001455575,0.00002152049,0.00001963562],"domain_scores_gemma":[0.9999747,0.000002734152,0.000008411845,0.000002543411,0.000003284426,0.000008139071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001076159,0.00006210302,0.00009705151,0.00001853904,0.000005415804,0.00002139618,0.000008322115,0.0002348444,0.997265,0.00005873037,0.00003479938,0.002086177],"study_design_scores_gemma":[0.00002919355,0.001037246,0.002408716,0.000001925325,0.00002263519,0.0001578697,0.000006812942,0.002630731,0.9924545,0.00001067914,0.001235244,0.000004416281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971712,0.0005523715,0.001292339,0.00002893229,0.000008523089,0.00001777211,0.00002746101,0.00004204507,0.000859355],"genre_scores_gemma":[0.9975845,0.0002758809,0.001107701,0.00001751395,0.000003365906,0.00001335291,0.00006874248,0.000005738451,0.00092324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006618056,"threshold_uncertainty_score":0.001909196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03604974424453965,"score_gpt":0.4232436732835745,"score_spread":0.3871939290390348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}