{"id":"W4408787466","doi":"10.1111/jnc.70048","title":"Hippocampal Inhibitory Interneuron‐Specific <scp>DREADDs</scp> Treatment Alters <scp>mTORC1</scp>‐<scp>4E</scp>‐<scp>BP</scp> Signaling and Impairs Memory Formation","year":2025,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; Université de Montréal; McGill University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"mTORC1; Hippocampal formation; Neuroscience; Inhibitory postsynaptic potential; Excitatory postsynaptic potential; Biology; Cell biology; Signal transduction; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008187403,0.00054385,0.0004016345,0.000269061,0.0001354868,0.000245091,0.0003191771,0.0003863705,0.002012233],"category_scores_gemma":[0.00006500597,0.0001617156,0.0003122744,0.0001464433,0.0003557561,0.000230158,0.0001542307,0.001004649,0.0003781129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003908333,"about_ca_system_score_gemma":0.0003189094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001743226,"about_ca_topic_score_gemma":0.004432069,"domain_scores_codex":[0.9998639,0.000008071019,0.00001477279,0.00003462865,0.00002955425,0.00004910135],"domain_scores_gemma":[0.9999181,0.000007847603,0.00002669212,0.000006219847,0.000007775706,0.00003341221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002278625,0.00003629533,0.00009139625,0.00003812045,0.000008417268,0.00003796637,0.000009474056,0.00003897814,0.9987537,0.00005244973,0.00005308691,0.0006522823],"study_design_scores_gemma":[0.00002920888,0.0004227386,0.002630646,0.000004516232,0.00002901714,0.00008272679,0.0000330153,0.0002625159,0.9956211,0.00002449274,0.0008551725,0.00000480393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971583,0.0004544901,0.0005354573,0.00007758687,0.00002887309,0.00001417136,0.0006959059,0.00008868747,0.0009465389],"genre_scores_gemma":[0.9931021,0.0008389585,0.0009930636,0.00008652577,0.000009092359,0.00006560999,0.0008337847,0.0000322579,0.004038629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002012233,"threshold_uncertainty_score":0.00673157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01038085585289289,"score_gpt":0.2328066033244908,"score_spread":0.2224257474715979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}