{"id":"W4408788345","doi":"10.1021/acs.analchem.4c03438","title":"Protein Recognition of Glycosphingolipids in Membranes: Mechanistic and Quantitative Insights","year":2025,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; National Cancer Institute; Ministry of Advanced Education, Government of Alberta","keywords":"Chemistry; Membrane; Biochemistry; Computational biology; Biophysics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005896346,0.0006140648,0.0003501225,0.0003267512,0.0002183882,0.0007318503,0.000547479,0.0007718219,0.0006198481],"category_scores_gemma":[0.0003885734,0.0001853681,0.0002837657,0.0002372298,0.0006270171,0.001305778,0.0004181321,0.001157704,0.0002468431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009915625,"about_ca_system_score_gemma":0.0003608041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001090553,"about_ca_topic_score_gemma":0.001028766,"domain_scores_codex":[0.9997928,0.00002850534,0.0000123999,0.00004520502,0.00008369744,0.00003754188],"domain_scores_gemma":[0.9998789,0.00004137678,0.00002961386,0.00001549569,0.00001883233,0.00001588242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005085013,0.00005964153,0.0006622029,0.0002341431,0.00001323223,0.00006680816,0.00004304775,0.001092529,0.9882519,0.00275293,0.0001240248,0.006648763],"study_design_scores_gemma":[0.000008427489,0.0001450783,0.004997205,0.00003091886,0.00002075208,0.0002312706,0.0001850741,0.0338881,0.9517254,0.004412952,0.004321063,0.00003394601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8958415,0.01215417,0.08399535,0.001896721,0.0001007029,0.00009725658,0.0008595924,0.0003441081,0.004710555],"genre_scores_gemma":[0.9623116,0.009679291,0.02568784,0.0004229081,0.0000431719,0.00007017749,0.0003709304,0.0000322062,0.0013819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001090553,"threshold_uncertainty_score":0.00719434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0180319793362665,"score_gpt":0.2997366062604832,"score_spread":0.2817046269242167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}