{"id":"W4408792198","doi":"10.1089/jmf.2024.k.0282","title":"A Mixture of Nicotinamide Mononucleotide, Decursin, and <scp>l</scp> -Cysteine Lowered Senescence-Associated Markers In Vitro and Was Effective Against 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis In Vivo: An Application of Network Pharmacology","year":2025,"lang":"en","type":"article","venue":"Journal of Medicinal Food","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Atopic dermatitis; In vivo; In vitro; Chemistry; Cysteine; Nicotinamide; Nicotinamide mononucleotide; Senescence; In vitro toxicology; Biochemistry; Pharmacology; Medicine; Immunology; Biology; Cell biology; Nicotinamide adenine dinucleotide; Biotechnology; Enzyme; NAD+ kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006412104,0.0001803561,0.0009041093,0.0004308955,0.00003577023,0.000004018549,0.0001092891,0.0002283482,0.000002057727],"category_scores_gemma":[0.0006085538,0.0001588479,0.0000759928,0.000489626,0.0001617091,0.0001156706,0.00003715101,0.0004460044,9.841145e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001004931,"about_ca_system_score_gemma":0.0002009965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003363788,"about_ca_topic_score_gemma":0.0001203191,"domain_scores_codex":[0.9981402,0.0003457543,0.00082565,0.0001879562,0.0002446628,0.0002558005],"domain_scores_gemma":[0.9980959,0.0007576213,0.0006176161,0.000113133,0.0002472799,0.0001683924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002803376,0.001346838,0.6494461,0.001421668,0.0008883846,0.0005469465,0.001554271,0.00008890253,0.324962,0.00006973679,0.002901669,0.01397003],"study_design_scores_gemma":[0.01412002,0.001904577,0.8999721,0.002477634,0.0006416534,0.0004223348,0.001523269,0.002047759,0.07587802,0.0008439761,0.0000825578,0.00008613653],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934992,0.004839176,0.0001296635,0.000570006,0.0002114648,0.0005382312,0.000008404503,0.000007006353,0.000196898],"genre_scores_gemma":[0.9985475,0.0006145585,0.0001814054,0.0005557695,0.00006361236,0.00001320601,0.000008188525,0.00001089585,0.000004863676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.250526,"threshold_uncertainty_score":0.6477631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005238420081644283,"score_gpt":0.2601413048883434,"score_spread":0.2549028848066991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}