{"id":"W4408792198","doi":"10.1089/jmf.2024.k.0282","title":"A Mixture of Nicotinamide Mononucleotide, Decursin, and <scp>l</scp> -Cysteine Lowered Senescence-Associated Markers In Vitro and Was Effective Against 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis In Vivo: An Application of Network Pharmacology","year":2025,"lang":"en","type":"article","venue":"Journal of Medicinal Food","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Atopic dermatitis; In vivo; In vitro; Chemistry; Cysteine; Nicotinamide; Nicotinamide mononucleotide; Senescence; In vitro toxicology; Biochemistry; Pharmacology; Medicine; Immunology; Biology; Cell biology; Nicotinamide adenine dinucleotide; Biotechnology; Enzyme; NAD+ kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009860689,0.0002978264,0.000257429,0.0001815664,0.0001024393,0.0001444684,0.000142322,0.0002595705,0.0007231651],"category_scores_gemma":[0.00006494804,0.00008972493,0.0001924446,0.00007974385,0.00009128459,0.0001344428,0.000108745,0.0003069467,0.0001227608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001797549,"about_ca_system_score_gemma":0.0001938871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007016089,"about_ca_topic_score_gemma":0.001993667,"domain_scores_codex":[0.9999158,0.00001623699,0.000007067432,0.00002640875,0.00002582776,0.000008609932],"domain_scores_gemma":[0.9999645,0.00000417971,0.00001025857,0.000003311621,0.000008210132,0.00000956613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008242347,0.00002155645,0.00006058712,0.00003495832,0.0000056505,0.000009803457,0.000002745851,0.00004083734,0.9983063,0.00001601807,0.0000117521,0.001407326],"study_design_scores_gemma":[0.000009734404,0.0007351562,0.0009837007,0.000004653607,0.00002483552,0.00006304571,0.000005816204,0.0003504424,0.9962595,0.00001160077,0.001548782,0.000002776258],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908515,0.003320453,0.003661007,0.00008454228,0.00003990768,0.00006295111,0.0002316042,0.00006788914,0.001680174],"genre_scores_gemma":[0.9922494,0.001506103,0.003283374,0.00005103736,0.000007820006,0.000036523,0.000247138,0.00001083439,0.002607864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007231651,"threshold_uncertainty_score":0.002419174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005238420081644283,"score_gpt":0.2601413048883434,"score_spread":0.2549028848066991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}