{"id":"W4408796584","doi":"10.1016/j.labinv.2024.103287","title":"1053 HER2 IHC Status as a Determinant for Trastuzumab Deruxtecan Eligibility in Endometrial Cancer","year":2025,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Trastuzumab; Endometrial cancer; Immunohistochemistry; Internal medicine; Medicine; Oncology; Cancer; Gynecology; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007054738,0.0001192435,0.000154384,0.0005322562,0.0002045841,0.0005592044,0.0002180285,0.000296963,0.002172618],"category_scores_gemma":[0.002517865,0.0001058093,0.0002456979,0.0004447151,0.0002252017,0.0002397836,0.0002424984,0.0002991947,0.0002322123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002728613,"about_ca_system_score_gemma":0.000440368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001856361,"about_ca_topic_score_gemma":0.003091345,"domain_scores_codex":[0.9997155,0.00008854487,0.00003716269,0.00002782996,0.00004210297,0.00008885413],"domain_scores_gemma":[0.998881,0.000487334,0.00027343,0.00003684956,0.00008828149,0.0002331546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004615599,0.00003751593,0.994805,0.000007537884,0.00002176918,0.0002545505,0.00003735684,0.00008452498,0.0008777042,0.00003676389,0.0001275271,0.003248203],"study_design_scores_gemma":[0.00001493822,0.0002390941,0.9958242,0.00001397757,0.0000634246,0.0009235734,0.0002769195,0.001092012,0.0006833473,0.00006146033,0.0008020599,0.000005093508],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998806,0.000173134,0.00003377494,0.00007041288,0.000006061013,0.000002614076,0.00005678857,0.000001628997,0.0008495932],"genre_scores_gemma":[0.9996374,0.00005697798,0.00004285402,0.00003074943,0.000008172042,0.000002157034,0.00005309175,9.941753e-7,0.0001675748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002172618,"threshold_uncertainty_score":0.007268131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01436002559030587,"score_gpt":0.3306159898514823,"score_spread":0.3162559642611764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}