{"id":"W4408796667","doi":"10.1016/j.labinv.2024.103669","title":"1430 Clinicopathologic and Molecular Analysis of Hepatocellular Carcinoma with RB1 Mutations/Deletions: A Distinct Non-Chromophobe Subset Featuring Abrupt Anaplasia","year":2025,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Anaplasia; Hepatocellular carcinoma; Biology; Pathology; Chromophobe cell; Carcinoma; Molecular biology; Genetics; Medicine; Clear cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003318017,0.0004602978,0.0002845109,0.001921088,0.0004434893,0.0005919207,0.0003368751,0.0003564186,0.002488772],"category_scores_gemma":[0.0009592633,0.0002967641,0.0001923463,0.0006725746,0.0005441845,0.0003140389,0.0004729764,0.0002489333,0.000682579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002267736,"about_ca_system_score_gemma":0.0002643913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008108362,"about_ca_topic_score_gemma":0.0009538415,"domain_scores_codex":[0.9997692,0.00002960431,0.00003067334,0.0000409705,0.00005677589,0.00007286942],"domain_scores_gemma":[0.9994141,0.0001528266,0.0001003817,0.0000530763,0.00007065729,0.0002089928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001542659,0.00009621231,0.698053,0.0000590548,0.00003904602,0.183582,0.0003828921,0.0002192366,0.1085468,0.000457272,0.0003038795,0.006717957],"study_design_scores_gemma":[0.00004339236,0.0004355511,0.6375049,0.00001131033,0.00008455043,0.3378129,0.0007005965,0.001523574,0.02015238,0.0003312471,0.001378076,0.0000215269],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972819,0.0001959659,0.0003601718,0.00003897363,0.000004806054,0.00001537871,0.00009861651,0.00002353485,0.001980687],"genre_scores_gemma":[0.9993743,0.00005625078,0.0002372639,0.0000125592,0.00001356399,0.000005518792,0.0001057174,0.000005349211,0.0001893694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002488772,"threshold_uncertainty_score":0.008325756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00712650316819365,"score_gpt":0.2379095293186964,"score_spread":0.2307830261505028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}