{"id":"W4408796667","doi":"10.1016/j.labinv.2024.103669","title":"1430 Clinicopathologic and Molecular Analysis of Hepatocellular Carcinoma with RB1 Mutations/Deletions: A Distinct Non-Chromophobe Subset Featuring Abrupt Anaplasia","year":2025,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Anaplasia; Hepatocellular carcinoma; Biology; Pathology; Chromophobe cell; Carcinoma; Molecular biology; Genetics; Medicine; Clear cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002559283,0.0001954094,0.0003242526,0.0002668359,0.0001123839,0.00003577396,0.0001158979,0.0001691175,0.000005100218],"category_scores_gemma":[0.0001483078,0.0001889783,0.00007639857,0.001446428,0.000299531,0.00001406987,0.00005024668,0.000110237,8.685331e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000213592,"about_ca_system_score_gemma":0.0003383637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007137227,"about_ca_topic_score_gemma":0.0001770894,"domain_scores_codex":[0.998758,0.0001288113,0.0003375683,0.0004513373,0.0001471202,0.0001771304],"domain_scores_gemma":[0.9988914,0.00002185836,0.0002126488,0.0004087492,0.0003692836,0.00009606808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00005624048,0.00003462451,0.3876945,0.00007574956,0.0002807916,0.000007086243,0.0001299056,0.0002965622,0.6107259,0.0002941654,0.0001718498,0.0002326567],"study_design_scores_gemma":[0.001057067,0.0002191495,0.5404442,0.00006032306,0.001451304,0.000005091293,0.0002103582,0.002361033,0.451023,0.0001966169,0.00264587,0.0003259882],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936771,0.003307049,0.002235624,0.00009209519,0.0001542033,0.0002717387,0.0001579883,0.00001713325,0.00008705477],"genre_scores_gemma":[0.9970392,0.0001502582,0.001553424,0.0002855258,0.00008133251,0.00007010593,0.0007542854,0.0000157833,0.00005005853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1597029,"threshold_uncertainty_score":0.7706313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00712650316819365,"score_gpt":0.2379095293186964,"score_spread":0.2307830261505028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}