{"id":"W4408796950","doi":"10.1016/j.labinv.2024.102278","title":"55 Spatial Transcriptomics Uncovers a Universal Fibroblastic Origin and Developmental Pathways in DICER1 Sarcoma","year":2025,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Metastasis and carcinoma case studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Centre for Applied Research in Cancer Control; BC Cancer Foundation; BC Cancer Agency; McGill University; University of British Columbia","funders":"","keywords":"Sarcoma; Transcriptome; Biology; Evolutionary biology; Computational biology; Cell biology; Pathology; Genetics; Medicine; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000154449,0.0001424401,0.0002321036,0.000187012,0.00008072269,0.00001953672,0.00003403028,0.0000690762,0.00002575114],"category_scores_gemma":[0.0001073493,0.0001385845,0.00002400578,0.0004885828,0.0001602515,0.0001234828,0.00002288828,0.0001410357,0.000007913302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002251351,"about_ca_system_score_gemma":0.0006375774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000131063,"about_ca_topic_score_gemma":0.0003895406,"domain_scores_codex":[0.9991591,0.00006776854,0.0002331944,0.0002323823,0.0001512192,0.0001563085],"domain_scores_gemma":[0.9996405,0.00005596883,0.00004376835,0.00008602881,0.00007939024,0.00009431057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004460523,0.0001103464,0.8087891,0.0006161174,0.0001711706,0.0002019977,0.005426292,0.00002192107,0.1580605,0.01696235,0.00375926,0.005434834],"study_design_scores_gemma":[0.007653296,0.0002770834,0.9028803,0.0008654053,0.0002915916,0.00002191111,0.008041168,0.001123727,0.05521799,0.001691725,0.02144351,0.0004922812],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997515,0.0003313416,0.000262065,0.0004612913,0.0001566112,0.0002446456,0.00005676945,0.00003617992,0.0009361583],"genre_scores_gemma":[0.997744,0.0000519593,0.001224997,0.0008075967,0.00003232139,0.00001341725,0.00004914855,0.000009542328,0.00006706716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1028425,"threshold_uncertainty_score":0.5651313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01966262518234802,"score_gpt":0.234204143050302,"score_spread":0.214541517867954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}