{"id":"W4408797489","doi":"10.1016/j.labinv.2024.103937","title":"1692 Shallow Whole Genome Copy Number Profiling of Squamous Cell Carcinoma Distinguishes Separate Primaries from Metastases","year":2025,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Centre for Applied Research in Cancer Control; Vancouver General Hospital; BC Cancer Foundation; BC Cancer Agency; University of British Columbia","funders":"","keywords":"Basal cell; Profiling (computer programming); Pathology; Genome; Biology; Carcinoma; Gene expression profiling; Medicine; Gene; Genetics; Gene expression; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001198785,0.0001637594,0.0001906847,0.00003309977,0.00008706468,0.00004674683,0.0001474363,0.0001159564,0.00001567774],"category_scores_gemma":[0.0003019724,0.000177583,0.00004918481,0.0001970168,0.0001677446,0.000008341922,0.00009285413,0.0000730301,0.000008943179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003536801,"about_ca_system_score_gemma":0.0005179841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001646133,"about_ca_topic_score_gemma":0.0001238841,"domain_scores_codex":[0.9990384,0.0000694742,0.0003009949,0.0003266314,0.0001015972,0.0001628879],"domain_scores_gemma":[0.9990793,0.00006005002,0.0001780139,0.000324852,0.000287421,0.0000703444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003990799,0.00003442945,0.1884333,0.00007987103,0.00002280681,0.000002083902,0.0001007061,0.0002868819,0.8091468,0.0005444473,0.001271617,0.00003709842],"study_design_scores_gemma":[0.0004824912,0.0000655945,0.02650711,0.00001346466,0.00007828727,1.782335e-7,0.0001228708,0.0000678393,0.9555364,0.0008929856,0.0160494,0.000183437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994596,0.001893659,0.0004370474,0.00008699881,0.0002317536,0.0002036956,0.001473702,0.00001463746,0.001062505],"genre_scores_gemma":[0.9930632,0.00003049691,0.003988795,0.0005244399,0.0001627605,0.00003330921,0.002027887,0.00001920016,0.0001499325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1619262,"threshold_uncertainty_score":0.7241624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008202036408190205,"score_gpt":0.2372214694219022,"score_spread":0.229019433013712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}