{"id":"W4408800412","doi":"10.1038/s41562-025-02121-9","title":"General anaesthesia decreases the uniqueness of brain functional connectivity across individuals and species","year":2025,"lang":"en","type":"article","venue":"Nature Human Behaviour","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Mila - Quebec Artificial Intelligence Institute; McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute on Drug Abuse; National Institute of Mental Health; National Institute on Aging; Canadian Institutes of Health Research; Health Canada; Fonds de recherche du Québec – Nature et technologies; McDonnell Center for Systems Neuroscience; Technische Universität München; Canada First Research Excellence Fund; Canada Research Chairs; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institutes of Health; U.S. Department of Health and Human Services; Government of Canada; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada; Canadian Institute for Advanced Research; Michael J. Fox Foundation for Parkinson's Research","keywords":"Unconsciousness; Macaque; Neuroscience; Propofol; Human brain; General anaesthesia; Optimal distinctiveness theory; Cognition; Psychology; Medicine; Anesthesia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005900119,0.0002289861,0.0002898927,0.0001274245,0.0009426641,0.00009213253,0.0002863373,0.0001830395,0.00004686256],"category_scores_gemma":[0.004066355,0.0001729172,0.0001051955,0.0004560178,0.0007408505,0.0001788191,0.0002838472,0.0006048172,0.000001545317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006381758,"about_ca_system_score_gemma":0.00008143661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009572732,"about_ca_topic_score_gemma":0.0003766776,"domain_scores_codex":[0.9981875,0.0003295942,0.000233577,0.0005481549,0.000420471,0.0002806831],"domain_scores_gemma":[0.9961323,0.003187982,0.0001396662,0.0003522108,0.000140858,0.00004699361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00006096042,0.0002309239,0.7541968,0.00002890718,0.00003726121,0.00001309496,0.0003564345,0.00002060162,0.06791545,0.1587869,0.01767323,0.0006794278],"study_design_scores_gemma":[0.0004517701,0.00006359789,0.9210237,0.00002836441,0.00003331157,0.00002099425,0.0002136273,0.000005968229,0.06862636,0.004758921,0.004618717,0.0001546685],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906354,0.0003712417,0.00005615035,0.007234068,0.0003310452,0.0003127173,0.0001218769,0.00007518571,0.0008623013],"genre_scores_gemma":[0.992229,0.00001452257,0.00003492181,0.005122384,0.0001047432,0.00004826558,0.000008553984,0.00001457751,0.002423069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1668269,"threshold_uncertainty_score":0.7250305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03466392254198573,"score_gpt":0.320211941631513,"score_spread":0.2855480190895273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}