{"id":"W4408805939","doi":"10.14740/wjon2547","title":"Increased Sirtuin 6 Activity in Tumor Cells Can Prompt CD4-Positive T-Cell Differentiation Into Regulatory T Cells and Impede Immune Surveillance in the Microenvironment","year":2025,"lang":"en","type":"article","venue":"World Journal of Oncology","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Immune system; Sirtuin; Tumor microenvironment; Cancer research; Cell biology; Immunology; Gene; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001141898,0.0002534288,0.0002465843,0.0001666002,0.0001342845,0.0002368327,0.0001289575,0.0002133073,0.001841059],"category_scores_gemma":[0.00008994501,0.0000747287,0.0003357066,0.0001834596,0.0001779671,0.0001568458,0.000122255,0.0004701927,0.0003993988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002260687,"about_ca_system_score_gemma":0.0001480303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002584254,"about_ca_topic_score_gemma":0.0006090382,"domain_scores_codex":[0.9998636,0.00001966356,0.00001022585,0.0000362912,0.00003507579,0.00003507274],"domain_scores_gemma":[0.9999369,0.000008244806,0.0000203694,0.000007006598,0.00001090199,0.00001660487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001785906,0.00002863412,0.000970296,0.00006446636,0.00001057731,0.00004042023,0.00001311431,0.00005962158,0.9963042,0.00004478547,0.00005922596,0.002226],"study_design_scores_gemma":[0.00002453363,0.000555121,0.009401633,0.000008133173,0.00003820569,0.0002268759,0.00005754858,0.0007221428,0.9851607,0.00007020718,0.003730123,0.000004846859],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886217,0.004751988,0.004061231,0.0001443705,0.0001030002,0.00002773698,0.000478467,0.0001109311,0.001700644],"genre_scores_gemma":[0.9944296,0.001233547,0.00224322,0.00008290263,0.00002707839,0.00002850713,0.0005663652,0.0000116419,0.001377018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001841059,"threshold_uncertainty_score":0.006159008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004495192078977108,"score_gpt":0.2474946897827361,"score_spread":0.242999497703759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}