{"id":"W4408806140","doi":"10.1101/2025.03.24.644915","title":"Structural determinants of rotavirus proteolytic activation","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Proteolysis; Infectivity; Spike (software development); Proteases; Biophysics; Trypsin; Cell biology; Rotavirus; Biology; Conformational change; Chemistry; Virus; Biochemistry; Virology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000200337,0.0002079777,0.0001640626,0.0001566164,0.0001255886,0.0004409119,0.0001759053,0.0002820306,0.001202742],"category_scores_gemma":[0.0004459158,0.0001667038,0.0002942131,0.0001190604,0.0002734791,0.0002249262,0.0002606569,0.00045993,0.0003531715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002625585,"about_ca_system_score_gemma":0.0001669884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004690454,"about_ca_topic_score_gemma":0.0004074677,"domain_scores_codex":[0.9998287,0.00003961292,0.00001433849,0.00002770544,0.00004049454,0.00004908309],"domain_scores_gemma":[0.9997105,0.00007960958,0.00008565078,0.00003282777,0.00003574885,0.00005563207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000152255,0.00001327358,0.001426996,0.00002656672,0.000005548659,0.0001889634,0.00002992511,0.000181534,0.9970873,0.0001944518,0.00002693695,0.00066622],"study_design_scores_gemma":[0.00002361333,0.0003260538,0.1063926,0.0000144937,0.00002144486,0.001890863,0.0001748522,0.002924327,0.8861309,0.0002370005,0.001847965,0.00001587597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976445,0.0003643532,0.001019173,0.00002837148,0.00000475207,0.000007007035,0.00008562267,0.00001299858,0.0008332554],"genre_scores_gemma":[0.9986772,0.0001474818,0.0006236775,0.00002056732,0.000003403384,0.000005621709,0.0002611721,0.000009579936,0.0002513278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001202742,"threshold_uncertainty_score":0.004023552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02931799733570652,"score_gpt":0.2996714153386477,"score_spread":0.2703534180029412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}