{"id":"W4408809005","doi":"10.1080/15548627.2025.2477443","title":"HMBOX1 reverses autophagy mediated 5-fluorouracil resistance through promoting HACE1-induced ubiquitination and degradation of ATG5 in colorectal cancer","year":2025,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Natural Science Foundation of China","keywords":"ATG5; Autophagy; Biology; Colorectal cancer; Cancer research; Downregulation and upregulation; Mouse model of colorectal and intestinal cancer; Cancer; Small interfering RNA; Ubiquitin; Transfection; Cell culture; Gene; Genetics; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009561038,0.0001923148,0.0002379763,0.000178553,0.0001009299,0.0001640016,0.0001068615,0.0001494196,0.0007415183],"category_scores_gemma":[0.00008892299,0.00007361387,0.0001413066,0.0001102544,0.0001029112,0.0001127902,0.0001092869,0.0002975948,0.0001189414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002848713,"about_ca_system_score_gemma":0.0001747585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005237839,"about_ca_topic_score_gemma":0.001572592,"domain_scores_codex":[0.9999498,0.000007457685,0.000005453235,0.00001108457,0.00001293519,0.00001313815],"domain_scores_gemma":[0.999964,0.000004110398,0.00001233566,0.000004253521,0.000004671236,0.00001066631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000384894,0.00005445745,0.0005319689,0.00008927083,0.00001241264,0.00003648887,0.0000123342,0.00008251849,0.9943604,0.00004086618,0.00007145032,0.00432294],"study_design_scores_gemma":[0.00006846259,0.001128483,0.02542695,0.00001140514,0.00005016713,0.0003593939,0.00003699928,0.001306584,0.9688182,0.00003962462,0.002746922,0.000006819434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961254,0.002488546,0.0006872431,0.00007161702,0.00002049627,0.00001583409,0.0001940689,0.00007481289,0.0003219742],"genre_scores_gemma":[0.9968425,0.00102654,0.0007894005,0.0000454869,0.000007254163,0.00001702841,0.0003466198,0.000007903707,0.0009172655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007415183,"threshold_uncertainty_score":0.002480626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0161566702040693,"score_gpt":0.3138457808950539,"score_spread":0.2976891106909846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}