{"id":"W4408809005","doi":"10.1080/15548627.2025.2477443","title":"HMBOX1 reverses autophagy mediated 5-fluorouracil resistance through promoting HACE1-induced ubiquitination and degradation of ATG5 in colorectal cancer","year":2025,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Natural Science Foundation of China","keywords":"ATG5; Autophagy; Biology; Colorectal cancer; Cancer research; Downregulation and upregulation; Mouse model of colorectal and intestinal cancer; Cancer; Small interfering RNA; Ubiquitin; Transfection; Cell culture; Gene; Genetics; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003063329,0.0002212,0.0004865556,0.0002041342,0.0000932668,0.00001820598,0.0001249427,0.0001865226,0.0001280541],"category_scores_gemma":[0.000554056,0.0002141174,0.00007355378,0.0006840518,0.0001014544,0.0002859511,0.00006590629,0.0002150605,0.000004518323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002141176,"about_ca_system_score_gemma":0.0004098031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003740868,"about_ca_topic_score_gemma":0.0003341888,"domain_scores_codex":[0.9983092,0.0001220441,0.0005560342,0.0004134859,0.000298466,0.0003007925],"domain_scores_gemma":[0.9990201,0.0002197974,0.0002552791,0.0002417846,0.0001932609,0.00006980468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001462753,0.0007758421,0.02041571,0.001422684,0.0004050636,0.0001905537,0.004106392,0.000009995204,0.9060879,0.009857395,0.0009531213,0.05431259],"study_design_scores_gemma":[0.00343235,0.0001647202,0.2927286,0.0008543986,0.0001223981,0.000006651384,0.0002329025,0.001103074,0.6982499,0.002250171,0.0006618191,0.0001929869],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903001,0.003977491,0.00007556717,0.001531787,0.0002117627,0.0005612728,0.00002459221,0.000107151,0.003210325],"genre_scores_gemma":[0.9961304,0.0006698956,0.0007138,0.0004322881,0.00005026352,0.0001305366,0.00006341233,0.00002349514,0.001785918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2723129,"threshold_uncertainty_score":0.8731456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0161566702040693,"score_gpt":0.3138457808950539,"score_spread":0.2976891106909846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}