{"id":"W4408814506","doi":"10.1038/s44161-025-00626-0","title":"Single-nucleus multi-omics implicates androgen receptor signaling in cardiomyocytes and NR4A1 regulation in fibroblasts during atrial fibrillation","year":2025,"lang":"en","type":"article","venue":"Nature Cardiovascular Research","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Fonds de Recherche du Québec - Santé; BHF Centre of Research Excellence, Oxford; British Heart Foundation; Wellcome Trust","keywords":"Biology; Gene; Gene expression; Cell biology; Atrial fibrillation; Cell; Cell type; Androgen receptor; Internal medicine; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006530113,0.0003124114,0.0005818562,0.0008213679,0.0004663059,0.0007433522,0.0001877487,0.0002375245,0.001203682],"category_scores_gemma":[0.0007662833,0.0001465771,0.0006766868,0.0008428507,0.0002809005,0.0002692796,0.0005047089,0.0002805807,0.0003267646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002612431,"about_ca_system_score_gemma":0.0003956296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002131652,"about_ca_topic_score_gemma":0.006925341,"domain_scores_codex":[0.9993741,0.00008886166,0.00005225741,0.0002949419,0.0001216372,0.00006813435],"domain_scores_gemma":[0.9995117,0.0001676808,0.0001505101,0.00006700107,0.00006269343,0.00004044551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007820308,0.00003420944,0.2887352,0.0007708487,0.001061385,0.0005754056,0.0004312857,0.001458169,0.6700727,0.0005385699,0.00132484,0.03421544],"study_design_scores_gemma":[0.00003001474,0.0001518517,0.9436787,0.0001326809,0.0008219038,0.0009890019,0.0004751478,0.004056354,0.03915232,0.001403047,0.009073952,0.0000350405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9616215,0.008315098,0.006963936,0.0003148122,0.00006156325,0.0000259623,0.02032348,0.0001723938,0.002201365],"genre_scores_gemma":[0.9778936,0.001620214,0.005359937,0.0002661381,0.00002532553,0.00005597209,0.01378608,0.0000668048,0.0009259577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002131652,"threshold_uncertainty_score":0.004238486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01885619452737142,"score_gpt":0.306258057031615,"score_spread":0.2874018625042435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}