{"id":"W4408817582","doi":"10.1021/acsomega.4c07038","title":"Quantitative Analysis of the Influence of Trehalose on Amyloid-β Binding to Membranes by Localized Surface Plasmon Resonance Spectroscopy","year":2025,"lang":"en","type":"article","venue":"ACS Omega","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Institute for Nanotechnology; University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Surface plasmon resonance; Membrane; Spectroscopy; Trehalose; Biophysics; Resonance (particle physics); Amyloid (mycology); Chemistry; Materials science; Nuclear magnetic resonance; Nanotechnology; Nanoparticle; Biochemistry; Biology; Physics; Atomic physics; Inorganic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006169342,0.0006963312,0.0003987455,0.0003200123,0.0002869654,0.0003881954,0.0004322522,0.0005229137,0.001363563],"category_scores_gemma":[0.000964079,0.0002075585,0.0003941638,0.0005180943,0.0003579647,0.0004552061,0.0002735842,0.0008914461,0.0003171276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002993282,"about_ca_system_score_gemma":0.0002201057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001144595,"about_ca_topic_score_gemma":0.001077365,"domain_scores_codex":[0.9994426,0.0001361903,0.00003629956,0.00009369465,0.0002179368,0.00007321245],"domain_scores_gemma":[0.9994116,0.0002357509,0.0001047266,0.00005394856,0.0001644457,0.00002964474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003182443,0.00001320228,0.00006296473,0.00003307866,0.000005289629,0.00001351003,0.00002712261,0.00008205214,0.9990562,0.00003438352,0.000009112913,0.0006313726],"study_design_scores_gemma":[0.000002538514,0.0001027958,0.001401467,0.000004461017,0.000009784758,0.00002607958,0.00004091253,0.001710907,0.9963527,0.00003219793,0.0003104341,0.000005850133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9571363,0.00171042,0.03740389,0.00008782723,0.0000491447,0.0001345531,0.0008196213,0.0001646283,0.002493699],"genre_scores_gemma":[0.9475917,0.002592891,0.04450628,0.0001039101,0.00002079116,0.0004674887,0.001073405,0.00009982155,0.003543739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001363563,"threshold_uncertainty_score":0.004561603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01752035150517319,"score_gpt":0.3396808521680063,"score_spread":0.3221605006628331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}