{"id":"W4408818812","doi":"10.1101/2025.03.23.644815","title":"The dichotomous impacts of semaphorin3E deficiency on exacerbating airway hyperresponsiveness, remodelling, and inflammation in type-2 low and type-2 high asthma models","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Asthma; Inflammation; Airway hyperresponsiveness; Immunology; Medicine; Airway; Bronchial hyperresponsiveness; Type (biology); Biology; Internal medicine; Lung; Respiratory disease; Ecology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003501998,0.0005556446,0.0004507938,0.0005083869,0.0002604768,0.0004514479,0.0002860945,0.000727482,0.002119085],"category_scores_gemma":[0.0001286776,0.0002510855,0.0006040994,0.0001742184,0.0005482579,0.0003710733,0.0003912357,0.001597524,0.0003613369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002888027,"about_ca_system_score_gemma":0.0003032618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004309693,"about_ca_topic_score_gemma":0.001028148,"domain_scores_codex":[0.999525,0.00009254572,0.00006416045,0.00008469357,0.0001109476,0.0001228019],"domain_scores_gemma":[0.9996958,0.00001971347,0.00007943845,0.00002958924,0.00002047473,0.0001550081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006368858,0.0002556615,0.0007958676,0.00005064664,0.00001012092,0.0001287173,0.00001615517,0.00004191461,0.9973084,0.0000652457,0.00004576202,0.0006446894],"study_design_scores_gemma":[0.0002436739,0.00627141,0.05127952,0.00004495605,0.0001281393,0.001969039,0.0003598118,0.001505312,0.9341952,0.0002176074,0.003757899,0.00002737462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969644,0.0007354705,0.0009081766,0.0001392122,0.0000441244,0.0000542252,0.000476882,0.00003809315,0.0006394853],"genre_scores_gemma":[0.9934849,0.0005801232,0.001507097,0.000174094,0.00002398755,0.0001443613,0.0007213023,0.00002632038,0.003337772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002119085,"threshold_uncertainty_score":0.007089078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01960375993228126,"score_gpt":0.2359845709942511,"score_spread":0.2163808110619698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}