{"id":"W4408823907","doi":"10.1182/blood.2024025653","title":"Destabilization of PF4-antigenic complexes in heparin-induced thrombocytopenia","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Heparin-Induced Thrombocytopenia and Thrombosis","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Heparin; Heparin-induced thrombocytopenia; Platelet factor 4; Chemistry; Antigen; Antithrombin; Platelet activation; Antibody; Monoclonal antibody; Platelet; Immune system; Immunology; Cell biology; Pharmacology; Biochemistry; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001878257,0.0002893448,0.0001746644,0.0001550091,0.0001137756,0.0001624998,0.000153524,0.0002846113,0.0008170786],"category_scores_gemma":[0.0002305527,0.0000786368,0.000126153,0.00009067555,0.0001612466,0.0001439777,0.000158971,0.0002216287,0.0001411746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001857238,"about_ca_system_score_gemma":0.0001062955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002083552,"about_ca_topic_score_gemma":0.0001523338,"domain_scores_codex":[0.9998693,0.00003789375,0.00001342146,0.00001952885,0.000026734,0.00003308299],"domain_scores_gemma":[0.9998971,0.00001854838,0.00004003169,0.000009563881,0.00001525991,0.0000194999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00026682,0.00005577353,0.0005482005,0.00007131631,0.00001077129,0.00006225672,0.00001392208,0.00007773264,0.9958727,0.00008877126,0.00003850501,0.002893235],"study_design_scores_gemma":[0.0000263702,0.0009608777,0.004176522,0.000004847769,0.00002515442,0.0003688919,0.000008157313,0.000562638,0.9924583,0.00003303069,0.001372334,0.000002752026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996518,0.001425592,0.001325344,0.00003388018,0.00001508062,0.0000222308,0.00002708386,0.00003299897,0.0005996532],"genre_scores_gemma":[0.9985698,0.0002394222,0.000684827,0.00003398499,0.000006238936,0.00001192043,0.0000536638,0.000004294481,0.0003957713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008170786,"threshold_uncertainty_score":0.002733469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0296167846319477,"score_gpt":0.3151513983916784,"score_spread":0.2855346137597307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}