{"id":"W4408831333","doi":"10.1128/spectrum.02523-24","title":"D-enantiomeric antibiofilm peptides effective against anaerobic <i>Cutibacterium acnes</i> biofilm","year":2025,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Biofilm; Microbiology; Bacteria; Internalization; Antimicrobial; Antibiotics; Chemistry; In vitro; Biology; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001184971,0.0003658018,0.0001851066,0.0001443234,0.00008041532,0.0001762173,0.0001405842,0.000206908,0.001128143],"category_scores_gemma":[0.0001393742,0.00008107086,0.0001747658,0.0001259865,0.0001179932,0.0001249648,0.0001626948,0.0002902286,0.0002067045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001260987,"about_ca_system_score_gemma":0.0001166125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002316603,"about_ca_topic_score_gemma":0.0003167387,"domain_scores_codex":[0.9998834,0.00002215753,0.00001653451,0.00001865335,0.00003427697,0.00002487302],"domain_scores_gemma":[0.9999007,0.00001910212,0.00002879834,0.000006435149,0.00001800625,0.00002696084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002438987,0.00004889996,0.0001324505,0.00007481919,0.000004939136,0.0000356672,0.000004210083,0.00007441521,0.9976916,0.00002181049,0.00003068203,0.001636474],"study_design_scores_gemma":[0.00004800878,0.00173959,0.003345284,0.00001496515,0.00002355992,0.0002440401,0.00002660813,0.0003194847,0.9917794,0.00001452171,0.002438372,0.000006227416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950493,0.002086186,0.0009913272,0.00004809642,0.00004215039,0.00004674976,0.0003493677,0.00001673507,0.001370066],"genre_scores_gemma":[0.9939469,0.001195348,0.003095037,0.00008328085,0.00001320912,0.00002949837,0.0005744872,0.00000881769,0.001053411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001128143,"threshold_uncertainty_score":0.003773987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004188516101569202,"score_gpt":0.2130669285336362,"score_spread":0.208878412432067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}