{"id":"W4408831444","doi":"10.1128/spectrum.01829-24","title":"The effect of molnupiravir and nirmatrelvir on SARS-CoV-2 genome diversity in severe models of COVID-19","year":2025,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Centre For Medical Engineering, King’s College London; Innovate UK; Engineering and Physical Sciences Research Council; National Institute of Allergy and Infectious Diseases; Medical Research Council; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Directorate for Biological Sciences; U.S. Food and Drug Administration; Medical Research Council Canada; Universität Zürich; Biotechnology and Biological Sciences Research Council; ViiV Healthcare; Wellcome Trust; Drugs for Neglected Diseases initiative; Gilead Sciences; National Science Foundation","keywords":"Immunosuppression; Context (archaeology); Biology; Immunology; Viral load; Virology; Mutation; Virus; Coronavirus; Coronavirus disease 2019 (COVID-19); Disease; Genetics; Medicine; Gene; Internal medicine; Infectious disease (medical specialty)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000665275,0.0001870955,0.000525308,0.0003186355,0.0001548181,0.000005985894,0.0002902493,0.0002066184,0.000003471731],"category_scores_gemma":[0.0001528239,0.0001288035,0.0001136754,0.0003527751,0.0005530466,0.00003157748,0.0004836846,0.0003590401,0.00001000271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002100624,"about_ca_system_score_gemma":0.0002089317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001151407,"about_ca_topic_score_gemma":0.000548317,"domain_scores_codex":[0.9986303,0.0002716987,0.0002989378,0.0003463248,0.00008266206,0.0003701047],"domain_scores_gemma":[0.9988018,0.0006452909,0.00008886578,0.0004140668,0.00002718026,0.00002285142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00224175,0.00009143689,0.1428885,0.0003483034,0.0001559097,0.00003714709,0.0003063086,0.0000100381,0.8520543,0.0008985411,0.0005436987,0.000424062],"study_design_scores_gemma":[0.006029627,0.002083388,0.01089659,0.0001000886,0.00009598741,0.00009298189,0.0001005971,0.0001682013,0.9601318,0.003225735,0.01688596,0.0001890503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933707,0.001358956,0.00005954814,0.001737496,0.00007421502,0.0006177989,0.00005204588,0.00002240383,0.002706833],"genre_scores_gemma":[0.990531,0.0000426816,0.00001190439,0.009314823,0.00001422873,0.00000989491,0.000006792886,0.000009002339,0.00005966723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1319919,"threshold_uncertainty_score":0.5252456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02726192773532429,"score_gpt":0.3189734516413485,"score_spread":0.2917115239060243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}