{"id":"W4408831444","doi":"10.1128/spectrum.01829-24","title":"The effect of molnupiravir and nirmatrelvir on SARS-CoV-2 genome diversity in severe models of COVID-19","year":2025,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Centre For Medical Engineering, King’s College London; Innovate UK; Engineering and Physical Sciences Research Council; National Institute of Allergy and Infectious Diseases; Medical Research Council; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Directorate for Biological Sciences; U.S. Food and Drug Administration; Medical Research Council Canada; Universität Zürich; Biotechnology and Biological Sciences Research Council; ViiV Healthcare; Wellcome Trust; Drugs for Neglected Diseases initiative; Gilead Sciences; National Science Foundation","keywords":"Immunosuppression; Context (archaeology); Biology; Immunology; Viral load; Virology; Mutation; Virus; Coronavirus; Coronavirus disease 2019 (COVID-19); Disease; Genetics; Medicine; Gene; Internal medicine; Infectious disease (medical specialty)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001700074,0.0003758594,0.0003735824,0.0002293256,0.000119076,0.0002113674,0.0002371918,0.0002650539,0.0008351328],"category_scores_gemma":[0.000105383,0.0001113405,0.0002720604,0.00009280574,0.0001900174,0.000211447,0.0001240561,0.00058093,0.000159028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001393893,"about_ca_system_score_gemma":0.0001777307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002926993,"about_ca_topic_score_gemma":0.0008183402,"domain_scores_codex":[0.9998447,0.00004306717,0.00001140813,0.00002510366,0.00003073797,0.00004491206],"domain_scores_gemma":[0.9998932,0.00001411175,0.00002957116,0.00001452016,0.000007455115,0.0000410439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001260874,0.0003625226,0.000292104,0.00004768694,0.00001144171,0.00005022897,0.00002295802,0.0001218004,0.9943982,0.00004928207,0.00005397561,0.003328854],"study_design_scores_gemma":[0.000160609,0.01743778,0.01060487,0.00001452611,0.00004528668,0.0003929084,0.00006400329,0.001359023,0.9667981,0.0000541084,0.003056898,0.0000118527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984492,0.0005990783,0.0002299872,0.00003506343,0.00002157605,0.00002155516,0.0001227349,0.0000272661,0.0004935929],"genre_scores_gemma":[0.9967624,0.0005637072,0.001027874,0.00004117829,0.00001649229,0.00004329995,0.0003337696,0.0000106931,0.001200589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008351328,"threshold_uncertainty_score":0.002793729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02726192773532429,"score_gpt":0.3189734516413485,"score_spread":0.2917115239060243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}