{"id":"W4408835378","doi":"10.1101/2025.03.20.25324216","title":"Pathway-Specific Polygenic Scores for Lithium Response for Predicting Clinical Lithium Treatment Response in Patients with Bipolar Disorder","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cilag; National Institute on Drug Abuse; Canadian Institutes of Health Research; Eli Lilly Japan; National Health and Medical Research Council; Allergan; Research Nova Scotia; Medical Research Council; Neuraxpharm; National Cancer Institute; Servier; National Institute of Mental Health; Stockholms Läns Landsting; Sanofi; Kyowa Hakko Kirin; Otsuka Pharmaceutical; Centro de Investigación Biomédica en Red de Salud Mental; Karolinska Institutet; Gedeon Richter; Generalitat de Catalunya; Bundesministerium für Bildung und Forschung; University of Adelaide; University of Oxford; Vetenskapsrådet; Virginia Commonwealth University; Eli Lilly and Company; Genome Canada; H. Lundbeck A/S; Centres de Recerca de Catalunya; Sunovion; Deutsche Forschungsgemeinschaft; University of Louisville; Ministerio de Ciencia e Innovación; European Commission; University of New South Wales; Rush University; Wayne State University; Johns Hopkins University; Dainippon Sumitomo Pharma; Ministry of Education, India; Pfizer; Bristol-Myers Squibb","keywords":"Bipolar disorder; Lithium (medication); Internal medicine; Medicine; Clinical psychology; Oncology; Psychology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001068836,0.0006801728,0.0003388804,0.001105,0.0002984944,0.0006518473,0.000292661,0.0004203231,0.002036219],"category_scores_gemma":[0.003059444,0.0001621285,0.001018897,0.001069258,0.0003104992,0.0003353525,0.000732354,0.0004762925,0.0002158206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002388542,"about_ca_system_score_gemma":0.0004004486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002769839,"about_ca_topic_score_gemma":0.003731371,"domain_scores_codex":[0.9992335,0.0003573693,0.00007449638,0.0001706984,0.00009641873,0.00006758508],"domain_scores_gemma":[0.9979745,0.000642482,0.0008365975,0.0001966891,0.0001656112,0.0001841819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002467664,0.00001398538,0.9955218,0.00001009393,0.0002273243,0.00004006486,0.00002200758,0.0003992385,0.0004404511,0.00003242306,0.0001004419,0.002945587],"study_design_scores_gemma":[0.00001410495,0.0001122115,0.9953839,0.000006787626,0.0001504205,0.0001885557,0.000046476,0.003616525,0.0001782896,0.000187602,0.0001084975,0.000006662724],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976252,0.0001594188,0.001006597,0.00005516149,0.000007503195,0.00001744633,0.0007337686,0.00001946324,0.0003754318],"genre_scores_gemma":[0.9987881,0.00003402106,0.000563634,0.00001113896,0.000005735739,0.00001194109,0.0005043654,0.000003014761,0.00007810636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002769839,"threshold_uncertainty_score":0.006811798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03336378573079506,"score_gpt":0.3164895653227266,"score_spread":0.2831257795919315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}