{"id":"W4408842203","doi":"10.1101/2025.03.24.645073","title":"Substrate recognition by the human mitochondrial processing peptidase and its processing of PINK1","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"PINK1; Substrate (aquarium); Chemistry; Mitochondrion; Cell biology; Computer science; Biochemistry; Biology; Mitophagy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001604222,0.0002828748,0.0001191962,0.00006879396,0.0001171033,0.0002597004,0.0001705684,0.0002208261,0.0008423541],"category_scores_gemma":[0.0001774596,0.0001245443,0.0001368907,0.00008366828,0.0001677425,0.0001803766,0.0001538862,0.0002940726,0.0005034442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00038054,"about_ca_system_score_gemma":0.000152629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004732287,"about_ca_topic_score_gemma":0.000378953,"domain_scores_codex":[0.9998868,0.00002612856,0.00001117717,0.00003536816,0.00002195113,0.00001860351],"domain_scores_gemma":[0.9999044,0.00001976514,0.0000314309,0.00001296162,0.000008219996,0.00002323502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009282696,0.00001084689,0.0002676004,0.00002259222,0.000002694753,0.0001052154,0.00001127423,0.0001098854,0.9984729,0.0001542108,0.00003763378,0.0007122576],"study_design_scores_gemma":[0.000009026572,0.00005090511,0.002675676,0.000002661012,0.000003628203,0.0004957123,0.00001449392,0.00159255,0.9935678,0.00006183556,0.001522983,0.000002833989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929028,0.001790894,0.00353223,0.0001682186,0.00002037913,0.00001493165,0.0002860865,0.00003782647,0.001246678],"genre_scores_gemma":[0.9930196,0.0007742499,0.003243989,0.00007058842,0.000009134006,0.00001424569,0.000787458,0.00001519407,0.002065489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008423541,"threshold_uncertainty_score":0.002817988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01776135143241031,"score_gpt":0.2437887910147457,"score_spread":0.2260274395823353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}