{"id":"W4408844916","doi":"10.3390/cells14070494","title":"Therapeutic Targets in Glioblastoma: Molecular Pathways, Emerging Strategies, and Future Directions","year":2025,"lang":"en","type":"review","venue":"Cells","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Glioblastoma; Medicine; Temozolomide; Radiation therapy; Brain tumor; Clinical trial; Bioinformatics; Biology; Cancer research; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00006720321,0.0003458472,0.001064599,0.0003515137,0.00005012668,0.00004886586,0.00006151819,0.0002348314,0.00006925447],"category_scores_gemma":[0.000004338995,0.0002589879,0.0002499217,0.0004817565,0.00002592684,0.00003948975,0.00003867537,0.0002822887,0.00001851438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000112167,"about_ca_system_score_gemma":0.0003346677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002258079,"about_ca_topic_score_gemma":0.0000281173,"domain_scores_codex":[0.9988564,0.00007793619,0.0003135888,0.0003886176,0.0001219113,0.0002416065],"domain_scores_gemma":[0.9994206,0.00007606544,0.00009127222,0.0002959491,0.00002719406,0.00008894648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000004021966,0.0002424311,0.000004066717,0.008768461,0.0002454397,0.0006228057,0.00008641607,4.485366e-7,0.00002790255,0.0006351755,0.0002354884,0.9891273],"study_design_scores_gemma":[0.0004263677,0.00008635152,0.00001495117,0.006713954,0.001093864,0.0000425647,0.0001513712,0.00000181306,0.0001375628,0.00007185758,0.9910793,0.0001800482],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007253655,0.9967502,0.000004907371,0.00009520313,0.0003916831,0.0008494845,0.0000253478,0.00004240939,0.001768221],"genre_scores_gemma":[0.0002683487,0.9990668,0.00006144951,0.00005878994,0.0001369726,0.0002141468,0.00005208563,0.0000328344,0.0001086091],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9908438,"threshold_uncertainty_score":0.9999862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01633403885954166,"score_gpt":0.2922298218060858,"score_spread":0.2758957829465441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}