{"id":"W4408844916","doi":"10.3390/cells14070494","title":"Therapeutic Targets in Glioblastoma: Molecular Pathways, Emerging Strategies, and Future Directions","year":2025,"lang":"en","type":"review","venue":"Cells","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Glioblastoma; Medicine; Temozolomide; Radiation therapy; Brain tumor; Clinical trial; Bioinformatics; Biology; Cancer research; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007207096,0.0008303682,0.001248263,0.001820159,0.0002609541,0.001081567,0.0007671352,0.0009265976,0.00342888],"category_scores_gemma":[0.0006799679,0.0002474213,0.0005986,0.001541899,0.0004891962,0.001409077,0.0005801074,0.001932149,0.001419644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007648876,"about_ca_system_score_gemma":0.001250454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001158209,"about_ca_topic_score_gemma":0.00309854,"domain_scores_codex":[0.9998292,0.00003620788,0.00002679469,0.00002609533,0.0000568034,0.00002476563],"domain_scores_gemma":[0.9997461,0.0001123626,0.00003667489,0.000007099716,0.00007354516,0.00002417743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001045318,0.0001024348,0.0001438772,0.01979389,0.00008245456,0.0002064456,0.00007981951,0.000555792,0.002207673,0.00713513,0.02700619,0.9425817],"study_design_scores_gemma":[0.00002626414,0.0001947657,0.0005885345,0.005992413,0.0001228927,0.0009443963,0.00008371793,0.0001641725,0.0004333188,0.003919643,0.9875114,0.00001857012],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001085975,0.9985672,0.00009074315,0.0004338204,0.000139087,0.000004792706,0.00001489657,0.000006568744,0.0006342616],"genre_scores_gemma":[0.0004813161,0.9987479,0.0001389551,0.0002318113,0.00008849891,0.000006338019,0.00001899212,0.000001025185,0.000285023],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00342888,"threshold_uncertainty_score":0.01147074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01633403885954166,"score_gpt":0.2922298218060858,"score_spread":0.2758957829465441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}