{"id":"W4408845645","doi":"10.1093/function/zqaf016","title":"Role of Pannexin 1, P2X7, and CFTR in ATP Release and Autocrine Signaling by Principal Cells of the Epididymis","year":2025,"lang":"en","type":"article","venue":"Function","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Fundação de Amparo à Pesquisa do Estado de São Paulo; Canada Foundation for Innovation","keywords":"Purinergic receptor; Autocrine signalling; Cell biology; Pannexin; Paracrine signalling; Epididymis; P2Y receptor; Purinergic signalling; Cystic fibrosis transmembrane conductance regulator; Endosome; Extracellular; Chemistry; Biology; Intracellular; Receptor; Gap junction; Biochemistry; Adenosine receptor; Connexin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001034573,0.00005190683,0.0000885887,0.00003068787,0.00001320357,0.000001701025,0.00003299692,0.00007109934,0.000005964034],"category_scores_gemma":[0.00003381019,0.00004073516,0.00001937066,0.00006597298,0.000046948,0.000001341306,0.0000598612,0.00004615603,9.220106e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000435195,"about_ca_system_score_gemma":0.00001982414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001524554,"about_ca_topic_score_gemma":0.0001277891,"domain_scores_codex":[0.9995854,0.00004263345,0.0001395955,0.0001368973,0.00002291886,0.00007255549],"domain_scores_gemma":[0.999809,0.00001420012,0.00004418679,0.0001037706,0.00001772384,0.00001115627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001467436,0.00002845683,0.03703935,0.00002388349,0.000008161423,1.211585e-7,0.00003374532,0.00003798715,0.9568224,0.00008091218,0.00007336081,0.005704878],"study_design_scores_gemma":[0.0006991346,0.0002207713,0.09911891,0.00003697814,0.00001370091,0.000001237537,0.0001618264,0.0004282327,0.8742961,0.0001841933,0.02477293,0.00006595571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979352,0.001484457,0.00007216563,0.0001004334,0.0000500536,0.00009255123,0.00000796962,0.000001388087,0.0002557398],"genre_scores_gemma":[0.9994642,0.0001063607,0.00002374038,0.00006870627,0.00001378463,0.000005265503,0.000009452217,0.000002717339,0.0003057665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08252627,"threshold_uncertainty_score":0.1661132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003141826216408131,"score_gpt":0.1994506138029078,"score_spread":0.1963087875864997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}