{"id":"W4408845645","doi":"10.1093/function/zqaf016","title":"Role of Pannexin 1, P2X7, and CFTR in ATP Release and Autocrine Signaling by Principal Cells of the Epididymis","year":2025,"lang":"en","type":"article","venue":"Function","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Fundação de Amparo à Pesquisa do Estado de São Paulo; Canada Foundation for Innovation","keywords":"Purinergic receptor; Autocrine signalling; Cell biology; Pannexin; Paracrine signalling; Epididymis; P2Y receptor; Purinergic signalling; Cystic fibrosis transmembrane conductance regulator; Endosome; Extracellular; Chemistry; Biology; Intracellular; Receptor; Gap junction; Biochemistry; Adenosine receptor; Connexin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001412502,0.0002975102,0.0002742744,0.0002532971,0.0002598324,0.0003873518,0.0002116556,0.0004134897,0.0006849174],"category_scores_gemma":[0.0000864074,0.0001325844,0.000258003,0.0001651418,0.0002873783,0.0005892155,0.0003637614,0.0004590676,0.000188821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002003358,"about_ca_system_score_gemma":0.000250058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006541222,"about_ca_topic_score_gemma":0.0006633158,"domain_scores_codex":[0.9998612,0.00001650225,0.00001188805,0.00003885827,0.00004044376,0.00003104677],"domain_scores_gemma":[0.999927,0.000007799839,0.00001908121,0.000006502458,0.00001208222,0.00002754689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001732893,0.00002069908,0.001253774,0.0001091153,0.000008658253,0.0004742079,0.00004755886,0.00004446615,0.9939817,0.0003129774,0.00005490941,0.003518656],"study_design_scores_gemma":[0.00006572866,0.0006164149,0.07066099,0.00002946539,0.00006378725,0.003483935,0.0003284238,0.001610626,0.9129527,0.0003652329,0.009804766,0.0000180349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9681647,0.02449777,0.003893564,0.000393987,0.00006230347,0.00003986696,0.0002152121,0.0000766093,0.002655976],"genre_scores_gemma":[0.9824412,0.01117577,0.002427797,0.000147185,0.00006750338,0.0000399304,0.0002891035,0.000009949013,0.003401672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006849174,"threshold_uncertainty_score":0.002291262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003141826216408131,"score_gpt":0.1994506138029078,"score_spread":0.1963087875864997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}