{"id":"W4408846024","doi":"10.1007/s12264-025-01386-4","title":"GALM Alleviates Aβ Pathology and Cognitive Deficit Through Increasing ADAM10 Maturation in a Mouse Model of Alzheimer’s Disease","year":2025,"lang":"en","type":"article","venue":"Neuroscience Bulletin","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"ADAM10; Presenilin; Long-term potentiation; Amyloid precursor protein; Hippocampal formation; Synaptic plasticity; Endocrinology; Galactose; Alzheimer's disease; Internal medicine; Neuroscience; Biology; Chemistry; Biochemistry; Metalloproteinase; Medicine; Enzyme; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003347333,0.001352287,0.0008776803,0.000890943,0.000343203,0.0005204171,0.0006030595,0.0009385188,0.00164127],"category_scores_gemma":[0.0002164685,0.0003257782,0.0007653992,0.0003123411,0.000681376,0.0006337825,0.0002649533,0.002507222,0.000446658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003805535,"about_ca_system_score_gemma":0.0005896279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009188412,"about_ca_topic_score_gemma":0.001211103,"domain_scores_codex":[0.9997681,0.00004074752,0.00003133567,0.00003869287,0.0000474976,0.00007364588],"domain_scores_gemma":[0.9997754,0.000013047,0.0000642007,0.00001797048,0.00003014078,0.00009926714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003712712,0.001120239,0.000349584,0.0003132004,0.00009255539,0.0002779056,0.00007680857,0.0001766344,0.9874917,0.0003693176,0.0004583035,0.005561064],"study_design_scores_gemma":[0.0009331621,0.007228028,0.009181645,0.00008849349,0.0004306805,0.0009069843,0.000247427,0.001867595,0.9703144,0.0007597372,0.007993981,0.00004784969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905064,0.003326371,0.002459469,0.0006951647,0.000295717,0.00007865181,0.0006678139,0.0005325957,0.001437944],"genre_scores_gemma":[0.9849133,0.004250181,0.004146871,0.0003360825,0.00007929146,0.0001864648,0.0009195891,0.00008064357,0.005087547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00164127,"threshold_uncertainty_score":0.005490601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04149010108886127,"score_gpt":0.3263245952180871,"score_spread":0.2848344941292258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}