{"id":"W4408848091","doi":"10.3390/vaccines13040351","title":"Systemic and Mucosal Antibody Responses to SARS-CoV-2 Variant-Specific Prime-and-Boost and Prime-and-Spike Vaccination: A Comparison of Intramuscular and Intranasal Bivalent Vaccine Administration in a Murine Model","year":2025,"lang":"en","type":"article","venue":"Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Institute of Infection and Immunity; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Bivalent (engine); Nasal administration; Virology; Vaccination; Spike Protein; Medicine; Antibody; Immunology; Biology; Coronavirus disease 2019 (COVID-19); Chemistry; Infectious disease (medical specialty); Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004053434,0.000888019,0.0005156836,0.0002783959,0.0001236762,0.0003261014,0.0002894058,0.0006126372,0.001211258],"category_scores_gemma":[0.0002147534,0.0002093654,0.0003388885,0.00009893626,0.0003381922,0.0004459354,0.0001366069,0.001453023,0.0003076644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003602409,"about_ca_system_score_gemma":0.0002955711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004340149,"about_ca_topic_score_gemma":0.0005836416,"domain_scores_codex":[0.9997671,0.0000403957,0.00001247522,0.00005849368,0.00004613959,0.00007532084],"domain_scores_gemma":[0.9998257,0.00002666067,0.00005033626,0.00002611316,0.00002056867,0.00005072196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009138377,0.0006979753,0.0002830765,0.00006367607,0.000009291567,0.00001805193,0.00002659248,0.0001870126,0.994165,0.0000602273,0.00006209001,0.003513177],"study_design_scores_gemma":[0.0001496378,0.02427851,0.004243213,0.00001525474,0.0000586799,0.0001775258,0.00003805669,0.001896305,0.9681337,0.00008330875,0.0009168434,0.000008869755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960944,0.0004963894,0.002083422,0.00006446938,0.00005276219,0.0000862347,0.0001600844,0.00009576558,0.0008665122],"genre_scores_gemma":[0.9953693,0.0003632272,0.002292491,0.00009363949,0.00004042183,0.00008229549,0.0002761125,0.00002202798,0.001460454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001211258,"threshold_uncertainty_score":0.004052043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03943410522194629,"score_gpt":0.3849363157523593,"score_spread":0.345502210530413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}