{"id":"W4408848091","doi":"10.3390/vaccines13040351","title":"Systemic and Mucosal Antibody Responses to SARS-CoV-2 Variant-Specific Prime-and-Boost and Prime-and-Spike Vaccination: A Comparison of Intramuscular and Intranasal Bivalent Vaccine Administration in a Murine Model","year":2025,"lang":"en","type":"article","venue":"Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Institute of Infection and Immunity; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Bivalent (engine); Nasal administration; Virology; Vaccination; Spike Protein; Medicine; Antibody; Immunology; Biology; Coronavirus disease 2019 (COVID-19); Chemistry; Infectious disease (medical specialty); Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007124604,0.0003412191,0.0008513746,0.0009082137,0.0001017182,0.000103128,0.000111059,0.0001938201,0.000002510221],"category_scores_gemma":[0.0002739531,0.0003010367,0.00004067932,0.0005991351,0.00004622939,0.0001820114,0.0002202926,0.0002831722,9.057047e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006686787,"about_ca_system_score_gemma":0.0002421879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001960391,"about_ca_topic_score_gemma":0.0002343203,"domain_scores_codex":[0.9977047,0.0001564897,0.000775747,0.0007119295,0.0003061375,0.0003449356],"domain_scores_gemma":[0.9988997,0.0002941437,0.0001339251,0.0003602117,0.0002258996,0.000086149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006861968,0.0004379197,0.4545539,0.001864525,0.0001537846,0.00008222671,0.0013524,0.000002716315,0.5175804,0.001714237,0.0002390016,0.01515687],"study_design_scores_gemma":[0.01027989,0.001730777,0.6567092,0.001251391,0.0002553136,0.0005322344,0.0005664489,0.03522392,0.2908924,0.0003384349,0.001742552,0.0004774582],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982443,0.01006094,0.003424302,0.002473203,0.00006506217,0.001396754,0.00001331538,0.00005104588,0.00007238844],"genre_scores_gemma":[0.9973059,0.0006427979,0.0008609174,0.001000071,0.00006485127,0.00005846125,0.0000111339,0.00002869648,0.00002718568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.226688,"threshold_uncertainty_score":0.9999442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03943410522194629,"score_gpt":0.3849363157523593,"score_spread":0.345502210530413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}