{"id":"W4408863348","doi":"10.1016/j.isci.2025.112293","title":"A central role for Numb/Nbl in multiple Shh-mediated axon repulsion processes","year":2025,"lang":"en","type":"article","venue":"iScience","topic":"Neurological disorders and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Fondation Fyssen; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Institut National de la Santé et de la Recherche Médicale; Sorbonne Université; Brain and Behavior Research Foundation; Fondation pour la Recherche Médicale; Canada Foundation for Innovation; National Alliance for Research on Schizophrenia and Depression; Canada Research Chairs; University of Iowa","keywords":"NUMB; Neuroscience; Chemistry; Cell biology; Nanotechnology; Biology; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005883074,0.00006989275,0.0001201219,0.000059662,0.00006637148,0.00001278232,0.00007866375,0.0000408809,0.00001498324],"category_scores_gemma":[0.001223098,0.00004869293,0.00002690081,0.0004794126,0.00006610861,0.00006128697,0.00002903836,0.00005858674,0.000006556593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002453444,"about_ca_system_score_gemma":0.0001023212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005485659,"about_ca_topic_score_gemma":0.00008837449,"domain_scores_codex":[0.9992407,0.000009323802,0.0001179424,0.0002707594,0.0001096819,0.000251577],"domain_scores_gemma":[0.9996333,0.0001254539,0.00002417488,0.0001074733,0.00005446747,0.00005513557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005611068,0.001260573,0.948492,0.0001864431,0.000008643733,0.00005654074,0.0003108365,0.00003782,0.02334918,0.0001111024,0.001783307,0.02384244],"study_design_scores_gemma":[0.005285403,0.0007856172,0.960454,0.0002062824,0.0000285857,0.000003354093,0.00028281,0.007578428,0.01335242,0.004322674,0.007554064,0.0001463151],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941217,0.0005076586,0.0002425988,0.002162389,0.00008596453,0.0005525437,0.000008934204,0.00003790475,0.002280353],"genre_scores_gemma":[0.9972802,0.00005406938,0.0003136628,0.001682252,0.000008390263,0.00005114573,0.00001062415,0.000002958569,0.0005966763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02369612,"threshold_uncertainty_score":0.198564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01923349289469616,"score_gpt":0.2881486926401451,"score_spread":0.268915199745449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}