{"id":"W4408863638","doi":"10.1016/j.clim.2025.110488","title":"BNT162b2 mRNA vaccination attenuates innate immune function in humans","year":2025,"lang":"en","type":"letter","venue":"Clinical Immunology","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trinity College","funders":"Science Foundation Ireland","keywords":"Innate immune system; Vaccination; Immune system; Immunology; Function (biology); Messenger RNA; Medicine; Biology; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity","insufficient_payload"],"category_scores_codex":[0.001422551,0.0007022333,0.001664817,0.001243475,0.0003649919,0.00005194016,0.001064965,0.005840195,0.002677402],"category_scores_gemma":[0.001548863,0.0006931481,0.0007217979,0.0006559506,0.00034123,0.0001923642,0.0005456853,0.007895649,0.002543911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002566268,"about_ca_system_score_gemma":0.0004153829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003447377,"about_ca_topic_score_gemma":0.00009559198,"domain_scores_codex":[0.9924088,0.002624232,0.002609061,0.001175352,0.00007730554,0.001105252],"domain_scores_gemma":[0.9945255,0.002847071,0.0008967036,0.001336273,0.0003786222,0.00001584821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001314398,0.0005685127,0.003030315,0.0001129811,0.002067022,0.0001315191,0.00008863943,0.000003127138,0.005455226,0.001146952,0.9332541,0.05282725],"study_design_scores_gemma":[0.003823201,0.0007807725,0.1106565,0.0001772669,0.0003157115,0.00003146227,0.00006038271,0.000004436642,0.000589499,0.001426039,0.8815409,0.0005938382],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.05365878,0.05496512,0.0003920004,0.844238,0.03444967,0.002292892,0.0002885449,0.0006804248,0.009034604],"genre_scores_gemma":[0.1690134,0.01412133,0.00008803769,0.4665111,0.002404312,0.000863918,0.01416587,0.0003069769,0.332525],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.3777269,"threshold_uncertainty_score":0.999552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03268124304377347,"score_gpt":0.3305170050215607,"score_spread":0.2978357619777872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}