{"id":"W4408863638","doi":"10.1016/j.clim.2025.110488","title":"BNT162b2 mRNA vaccination attenuates innate immune function in humans","year":2025,"lang":"en","type":"letter","venue":"Clinical Immunology","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trinity College","funders":"Science Foundation Ireland","keywords":"Innate immune system; Vaccination; Immune system; Immunology; Function (biology); Messenger RNA; Medicine; Biology; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008923452,0.0002952976,0.0004153879,0.0001068029,0.00043806,0.0005080533,0.0002070623,0.003540878,0.002147602],"category_scores_gemma":[0.002023922,0.000120311,0.0002275195,0.00006200424,0.0005887945,0.0003135746,0.0001335321,0.002129948,0.0009984538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008097269,"about_ca_system_score_gemma":0.000416706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001119451,"about_ca_topic_score_gemma":0.0009403774,"domain_scores_codex":[0.9996837,0.0001396603,0.00001833542,0.00003672895,0.00005885855,0.00006272006],"domain_scores_gemma":[0.9993883,0.0003539682,0.0000515603,0.00004745271,0.00007394185,0.00008471228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.00834531,0.001063729,0.02555375,0.0003852283,0.0001602646,0.05118648,0.0004334586,0.000693211,0.04891022,0.01191688,0.6585559,0.1927956],"study_design_scores_gemma":[0.002436233,0.005122021,0.02905604,0.0003801418,0.0002164942,0.05056735,0.0005285094,0.004711452,0.03088602,0.01635716,0.8596464,0.00009220547],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1742893,0.01621929,0.004618672,0.7164335,0.03742767,0.000161922,0.0003080636,0.000417964,0.05012358],"genre_scores_gemma":[0.5373947,0.006979166,0.001502271,0.3861825,0.02988042,0.0001418014,0.0001346028,0.0001006914,0.03768387],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.003540878,"threshold_uncertainty_score":0.007184505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03268124304377347,"score_gpt":0.3305170050215607,"score_spread":0.2978357619777872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}