{"id":"W4408863646","doi":"10.36401/iddb-24-7","title":"Structure and Roles of Phospholipase C (PLC), Phosphatidylinositol 4,5-bisphosphate (PIP2), and Inositol 1,4,5-trisphosphate (IP3) in Metabolism and Disease: A Systematic Review","year":2025,"lang":"en","type":"review","venue":"Innovations in Digital Health Diagnostics and Biomarkers","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Inositol; Phosphatidylinositol 4,5-bisphosphate; Phosphatidylinositol; Phospholipase C; Biochemistry; Inositol trisphosphate; Chemistry; Cell biology; Biology; Enzyme; Signal transduction; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005111014,0.0005517865,0.001855274,0.0004439155,0.0001122597,0.000129217,0.0001598241,0.0003025399,0.000001703788],"category_scores_gemma":[0.001894135,0.0004825299,0.00009559591,0.001058126,0.0002631282,0.0000399573,0.000303881,0.0002336386,1.610506e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004194314,"about_ca_system_score_gemma":0.0006322716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004303485,"about_ca_topic_score_gemma":0.00004487346,"domain_scores_codex":[0.9968687,0.0001293801,0.001694896,0.0007219549,0.0002123964,0.0003726917],"domain_scores_gemma":[0.9980594,0.0003186041,0.0008006494,0.0003917487,0.0001614729,0.0002681464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.00004745484,0.0001102872,0.001324295,0.7900601,0.0001903357,0.00002268351,0.00004188201,7.525246e-7,0.000003903591,0.001628072,0.0003945978,0.2061756],"study_design_scores_gemma":[0.002069116,0.0001803917,0.002403036,0.9389033,0.001116079,0.00008293252,0.00009315757,0.00009384543,0.000185766,0.001103016,0.05240611,0.001363262],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002906288,0.991919,0.0000346523,0.0003095909,0.00008578238,0.003326675,0.001397135,0.00001019558,0.00001061234],"genre_scores_gemma":[0.01023537,0.987776,0.0002552426,0.0004929037,0.00002106021,0.0002798044,0.0008824558,0.00003422643,0.00002287201],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.2048124,"threshold_uncertainty_score":0.9997627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01024164521729276,"score_gpt":0.2994377070366439,"score_spread":0.2891960618193511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}