{"id":"W4408865027","doi":"10.1021/acs.biochem.4c00780","title":"Interaction of CFTR Modulators with Mammalian Membrane Mimetics: The Role of Cholesterol","year":2025,"lang":"en","type":"article","venue":"Biochemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Hospital for Sick Children; Cystic Fibrosis Canada","keywords":"Chemistry; Cholesterol; Biophysics; Membrane; Cell biology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002512091,0.0002988777,0.0003735705,0.0001823004,0.0001894764,0.0003808144,0.0002438942,0.0004515366,0.0006069231],"category_scores_gemma":[0.0003766363,0.0001018912,0.0002450805,0.0001520527,0.0001955937,0.0002940827,0.0002520831,0.0003305817,0.0001970157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003284173,"about_ca_system_score_gemma":0.0001640603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006468407,"about_ca_topic_score_gemma":0.0005729891,"domain_scores_codex":[0.9997426,0.00008162733,0.00001692724,0.00003985532,0.00006167592,0.00005724674],"domain_scores_gemma":[0.9999168,0.00003029427,0.00001857742,0.00001028819,0.00001152476,0.00001247557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003504172,0.00004886167,0.0005640422,0.00009467431,0.00001694114,0.00008403524,0.00003417773,0.0001488916,0.9948836,0.0001835947,0.0000792707,0.003511489],"study_design_scores_gemma":[0.00002901986,0.000441177,0.002160027,0.00001171413,0.00001917178,0.0001925468,0.00003298093,0.001048728,0.9934402,0.00002813743,0.00258931,0.000006953339],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906977,0.005704026,0.001715051,0.000197198,0.00003299814,0.00005227399,0.00009956217,0.00003285621,0.001468335],"genre_scores_gemma":[0.9942028,0.002572639,0.001820697,0.000124064,0.00001535334,0.00003978549,0.0001473909,0.000006838507,0.001070362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006468407,"threshold_uncertainty_score":0.002382874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003360403645474326,"score_gpt":0.2411779169372519,"score_spread":0.2378175132917776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}