{"id":"W4408873161","doi":"10.1038/s41589-025-01869-5","title":"Reversible histone deacetylase activity catalyzes lysine acylation","year":2025,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia, Okanagan Campus; University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Institute on Aging; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; University of California, San Francisco; U.S. Department of Health and Human Services","keywords":"Acylation; Lysine; Chemistry; Histone deacetylase; Acetylation; Histone; Histone deacetylase 5; HDAC11; Biochemistry; Histone deacetylase 2; Computational biology; Cell biology; Biology; Amino acid; Catalysis; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00038596,0.0006653633,0.0003288165,0.0003051432,0.0003229881,0.0004797836,0.0007982692,0.0003481701,0.00427073],"category_scores_gemma":[0.0002776535,0.0003536845,0.0004197838,0.0002746329,0.0004157333,0.0004601677,0.000593741,0.001167214,0.001745891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008622634,"about_ca_system_score_gemma":0.0005358272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001216276,"about_ca_topic_score_gemma":0.002352115,"domain_scores_codex":[0.9996692,0.00003012224,0.00001731927,0.00009865518,0.0001105651,0.00007421368],"domain_scores_gemma":[0.9998803,0.00002218988,0.00002991584,0.00002435532,0.00001800305,0.00002519467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002087178,0.00007505656,0.0003400455,0.0002033475,0.00004851958,0.0001055081,0.00002953233,0.0002637988,0.977042,0.003394739,0.0005975006,0.01769119],"study_design_scores_gemma":[0.00001065072,0.00006744838,0.0001686683,0.00000230281,0.000009265174,0.00004369213,0.000003739238,0.0001516703,0.9955629,0.00009270094,0.003882691,0.000004264743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7887787,0.01934004,0.1278018,0.00173497,0.001763228,0.0004465861,0.002088656,0.00297421,0.05507192],"genre_scores_gemma":[0.96943,0.004363485,0.008290602,0.000135226,0.000106915,0.00005045381,0.001035746,0.00008011174,0.01650744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00427073,"threshold_uncertainty_score":0.01428699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005859235197974469,"score_gpt":0.3228663041940267,"score_spread":0.3170070689960522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}