{"id":"W4408874816","doi":"10.3389/fsybi.2025.1473338","title":"A promising novel strain of L. reuteri DSM20016 as a chassis for synthetic biology applications","year":2025,"lang":"en","type":"article","venue":"Frontiers in Synthetic Biology","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); University of Toronto","funders":"","keywords":"Chassis; Strain (injury); Biology; Synthetic biology; Computational biology; Engineering; Mechanical engineering; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003606023,0.001080361,0.0005484411,0.0006709999,0.000321155,0.000825081,0.0008635375,0.0008198567,0.001216741],"category_scores_gemma":[0.0003047298,0.0002516552,0.0005334325,0.0008496192,0.0002203432,0.0004092233,0.0006946063,0.0009012888,0.001544556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003647559,"about_ca_system_score_gemma":0.0004808893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009034481,"about_ca_topic_score_gemma":0.001407885,"domain_scores_codex":[0.999597,0.00007224808,0.00006669713,0.0000768074,0.0001416663,0.00004552363],"domain_scores_gemma":[0.9998686,0.00001107647,0.0000319169,0.00002745291,0.00002641017,0.00003445906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009766011,0.00008677956,0.0002554778,0.00009952211,0.000007450155,0.00009368381,0.00002005359,0.0001735056,0.9941,0.0001987713,0.0002023541,0.004664661],"study_design_scores_gemma":[0.00004355042,0.0006654444,0.002443007,0.00004085865,0.00004164961,0.0007088961,0.0001160876,0.001265688,0.9630374,0.0001997826,0.03140705,0.00003054646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9408505,0.003837262,0.0372345,0.001552624,0.0003485056,0.0006799357,0.005909534,0.0008571905,0.00873007],"genre_scores_gemma":[0.8318919,0.004040044,0.1209005,0.0004201516,0.00008526198,0.0007057558,0.02355742,0.0003403994,0.0180585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001216741,"threshold_uncertainty_score":0.004070401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006553405028856751,"score_gpt":0.2620362394139817,"score_spread":0.2554828343851249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}